ArticleJournal of clinical microbiology2014
Multiple-strain colonization in nasal carriers of Staphylococcus aureus.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
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- Culture-enriched metagenomic sequencing reveals within-patient diversity and transmission of vancomycin-resistantmedRxiv : the preprint server for health sciences · 2026Article
- High-throughput targeted amplicon screening tool for characterizing intrahost diversity inMicrobial genomics · 2025Article
- Multi-strain carriage and intrahost diversity ofMicrobial genomics · 2025Article
- The mutational landscape of Staphylococcus aureus during colonisation.Nature communications · 2025Article
- Nasopharyngeal carriage and antibiotic susceptibility patterns ofAfrican health sciences · 2023Article
- The intra-host evolutionary landscape and pathoadaptation of persistentMicrobial genomics · 2023Article
- Selection ofFrontiers in cellular and infection microbiology · 2022Article
- Right-sided endocarditis caused by polyclonal Staphylococcus aureus infection.European journal of medical research · 2021Article
- A Comprehensive View on the Human Antibody Repertoire AgainstFrontiers in immunology · 2021Observational
- The Epidome - a species-specific approach to assess the population structure and heterogeneity of Staphylococcus epidermidis colonization and infection.BMC microbiology · 2020Article
- Transmission and Long-Term Colonization Patterns ofInternational journal of environmental research and public health · 2020Article
- Article
- Co-occurrence of carbapenemase encoding genes in Acinetobacter baumannii, a dream or reality?BMC microbiology · 2018Article
- The Microevolution and Epidemiology of Staphylococcus aureus Colonization during Atopic Eczema Disease Flare.The Journal of investigative dermatology · 2018Article
- Genomic evolution of Staphylococcus aureus isolates colonizing the nares and progressing to bacteremia.PloS one · 2018Article
- Challenges in Estimating Characteristics ofFrontiers in public health · 2018Article
- Longitudinal study of Staphylococcus aureus colonization and infection in a cohort of swine veterinarians in the United States.BMC infectious diseases · 2017Article
- Whole-Genome Sequencing Reveals the Contribution of Long-Term Carriers in Staphylococcus aureus Outbreak Investigation.Journal of clinical microbiology · 2017Article
- Multi-site and nasal swabbing for carriage of Staphylococcus aureus: what does a single nose swab predict?The Journal of hospital infection · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Staphylococcus aureus is a commensal that can also cause invasive infection. Reports suggest that nasal cocolonization occurs rarely, but the resources required to sequence multiple colonies have precluded its large-scale investigation. A staged protocol was developed to maximize detection of mixed-spa-type colonization while minimizing laboratory resources using 3,197 S. aureus-positive samples from a longitudinal study of healthy individuals in Oxfordshire, United Kingdom. Initial typing of pooled material from each sample identified a single unambiguous strain in 89.6% of samples. Twelve single-colony isolates were typed from samples producing ambiguous initial results. All samples could be resolved into one or more spa types using the protocol. Cocolonization point prevalence was 3.4 to 5.8% over 24 months of follow-up in 360 recruitment-positives. However, 18% were cocolonized at least once, most only transiently. Cocolonizing spa types were completely unrelated in 56% of samples. Of 272 recruitment-positives returning ≥12 swabs, 166 (61%) carried S. aureus continuously but only 106 (39%) carried the same single spa type without any cocolonization; 31 (11%) switched spa type and 29 (11%) had transient cocarriage. S. aureus colonization is dynamic even in long-term carriers. New unrelated cocolonizing strains could increase invasive disease risk, and ongoing within-host evolution could increase invasive potential, possibilities that future studies should explore.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.