ArticleNeurourology and urodynamics2015
Long-term effects of simulated childbirth injury on function and innervation of the urethra.
Article in Neurourology and urodynamics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Age at first birth and risk of urinary incontinence after delivery: a dose-response meta-analysis.Scientific reports · 2022Pooled it
- Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies.International journal of molecular sciences · 2022Pooled it
- Multiparity, age and overweight/obesity as risk factors for urinary incontinence in pregnancy: a systematic review and meta-analysis.International urogynecology journal · 2018Pooled it
- Urethral injury during vaginal delivery: Incidence, management and long-term outcomes.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture.Open medicine (Warsaw, Poland) · 2025Article
- Pelvic floor parameters predict postpartum stress urinary incontinence: a prospective MRI study.Insights into imaging · 2023Article
- Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction.Cell & bioscience · 2023Review
- Brain-Derived Neurotrophic Factor Is Indispensable to Continence Recovery after a Dual Nerve and Muscle Childbirth Injury Model.International journal of molecular sciences · 2023Article
- Time course for urethral neuromuscular reestablishment and its facilitated recovery by transcutaneous neuromodulation after simulated birth trauma in rats.Scientific reports · 2021Article
- Ultrasound imaging of maternal birth trauma.International urogynecology journal · 2021Review
- Multiple doses of stem cells maintain urethral function in a model of neuromuscular injury resulting in stress urinary incontinence.American journal of physiology. Renal physiology · 2019Article
- Daily bilateral pudendal nerve electrical stimulation improves recovery from stress urinary incontinence.Interface focus · 2019Article
- Electrical stimulation of the pudendal nerve promotes neuroregeneration and functional recovery from stress urinary incontinence in a rat model.American journal of physiology. Renal physiology · 2018Article
- Multiparity affects conduction properties of pelvic floor nerves in rabbits.Brain and behavior · 2018Article
- Non-invasive electromyographic estimation of motor unit number in the external anal sphincter of the rat.Neurourology and urodynamics · 2018Article
- Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats.American journal of physiology. Renal physiology · 2016Article
- Mesenchymal stem cells and their secretome partially restore nerve and urethral function in a dual muscle and nerve injury stress urinary incontinence model.American journal of physiology. Renal physiology · 2015Article
- Article
- Brain-derived neurotrophic factor in urinary continence and incontinence.Nature reviews. Urology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
aimsPudendal nerve and external urethral sphincter (EUS) injury during vaginal delivery are risk factors for stress urinary incontinence (SUI). Although most patients with short-term postpartum SUI regain continence within 1 year, they have a higher predisposition to develop recurrent SUI years later, suggesting a possible mechanistic relationship. In contrast, animal models generally recover spontaneously and have not been studied much in the long term. The aim of this study was to investigate the long-term effects of simulated childbirth injury in rats.
methodsThirty-four Sprague-Dawley female rats underwent sham injury or pudendal nerve crush and vaginal distension (PNC + VD), a simulated childbirth injury. Nine weeks later, leak point pressure (LPP) and EUS electromyography (EMG) were recorded simultaneously. The pudendal nerve was harvested for histological analysis. EUS neuromuscular junctions (NMJs) and their innervation were qualitatively assessed using immunofluorescence. A t-test was used to compare quantitative outcomes between groups, with P < 0.05 indicating a significant difference.
resultsThere was no significant difference in LPP or EUS EMG amplitude or firing rate between the two groups. Nonetheless after PNC + VD, NMJs in the EUS were diffuse and were innervated by tortuous and multiple axons, demonstrating that reinnervation of the EUS was still in progress.
conclusionsAlthough continence function recovered 9 weeks after simulated childbirth injury, innervation of EUS was not complete at this time point, suggestive of persistent neurogenic deficiency which when compounded by the effects of aging may lead to a delayed recurrence of SUI in this animal model with increased age.
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