ReviewThe Journal of nutrition2014
Walnuts have potential for cancer prevention and treatment in mice.
Review in The Journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Systemic Inflammation and the Inflammatory Context of the Colonic Microenvironment Are Improved by Urolithin A.Cancer prevention research (Philadelphia, Pa.) · 2025Article
- Computational identification of PDL1 inhibitors and their cytotoxic effects with silver and gold nanoparticles.Scientific reports · 2024Article
- Neuroprotective effects of walnutIranian journal of basic medical sciences · 2024Review
- Dietary Walnuts Preserve Aspects of Health Span and Alter the Hippocampal Lipidome in Aged High-Fat Diet-Fed Mice.International journal of molecular sciences · 2023Article
- Review
- The Analysis of Phenolic Compounds in Walnut Husk and Pellicle by UPLC-Q-Orbitrap HRMS and HPLC.Molecules (Basel, Switzerland) · 2021Article
- Assessment of Total Fat and Fatty Acids in Walnuts Using Near-Infrared Hyperspectral Imaging.Frontiers in plant science · 2021Article
- Proteome Analysis of Walnut Bacterial Blight Disease.International journal of molecular sciences · 2020Article
- Profiling Anticancer and Antioxidant Activities of Phenolic Compounds Present in Black Walnuts (Molecules (Basel, Switzerland) · 2020Article
- Morphological and Compositional Analysis of Two Walnut (Juglans regia L.) Cultivars Growing in China.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Article
- Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk.Current breast cancer reports · 2018Article
- Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis.Frontiers in nutrition · 2018Article
- Walnut Supplementation in the Diet Reduces Oxidative Damage and Improves Antioxidant Status in Transgenic Mouse Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Article
- Prebiotic nut compounds and human microbiota.Critical reviews in food science and nutrition · 2017Review
- Protective Effect of Juglans regia L. Walnut Extract Against Oxidative DNA Damage.Plant foods for human nutrition (Dordrecht, Netherlands) · 2017Article
- Effect of β-sitosterol against methyl nitrosourea-induced mammary gland carcinoma in albino rats.BMC complementary and alternative medicine · 2016Article
- Coevolution between Cancer Activities and Food Structure of Human Being from Southwest China.BioMed research international · 2015Review
- Omega-3 Polyunsaturated Fatty Acids Intake to Regulate Helicobacter pylori-Associated Gastric Diseases as Nonantimicrobial Dietary Approach.BioMed research international · 2015Review
- Communicating clinical research to reduce cancer risk through diet: Walnuts as a case example.Nutrition research and practice · 2014Review
- What comes first: the food or the nutrient? Executive summary of a symposium.The Journal of nutrition · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cancer may not be completely the result of novel or inherited genetic mutations but may in fact be a largely preventable disease. Researchers have identified biochemicals, including n-3 (ω-3) fatty acids, tocopherols, β-sitosterol, and pedunculagin, that are found in walnuts and that have cancer-prevention properties. Mouse studies in which walnuts were added to the diet have shown the following compared with the control diet: (1) the walnut-containing diet inhibited the growth rate of human breast cancers implanted in nude mice by ∼80%; (2) the walnut-containing diet reduced the number of mammary gland tumors by ∼60% in a transgenic mouse model; (3) the reduction in mammary gland tumors was greater with whole walnuts than with a diet containing the same amount of n-3 fatty acids, supporting the idea that multiple components in walnuts additively or synergistically contribute to cancer suppression; and (4) walnuts slowed the growth of prostate, colon, and renal cancers by antiproliferative and antiangiogenic mechanisms. Cell studies have aided in the identification of the active components in walnuts and of their mechanisms of action. This review summarizes these studies and presents the notion that walnuts may be included as a cancer-preventive choice in a healthy diet.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.