ArticleImmunogenetics2014
Genomic characteristics of the T cell receptor (TRB) locus in the rabbit (Oryctolagus cuniculus) revealed by comparative and phylogenetic analyses.
Article in Immunogenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- IMGTAntibodies (Basel, Switzerland) · 2026Review
- Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma.Open medicine (Warsaw, Poland) · 2025Article
- Genomic characterization of the T-cell receptor loci inFrontiers in immunology · 2025Article
- A Comprehensive Analysis of the Genomic and Expressed Repertoire of the T-Cell Receptor Beta Chain inAnimals : an open access journal from MDPI · 2024Article
- Squamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus.Frontiers in immunology · 2024Article
- Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids.Frontiers in immunology · 2021Article
- The expansion of the TRB and TRG genes in domestic goats (Capra hircus) is characteristic of the ruminant species.BMC genomics · 2020Article
- Review
- Characterization of the ferret TRB locus guided by V, D, J, and C gene expression analysis.Immunogenetics · 2020Review
- Topology and expressed repertoire of the Felis catus T cell receptor loci.BMC genomics · 2020Article
- IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based onFrontiers in immunology · 2020Article
- The Camel Adaptive Immune Receptors Repertoire as a Singular Example of Structural and Functional Genomics.Frontiers in genetics · 2019Review
- Comparative Analysis of the TRB Locus in theFrontiers in genetics · 2019Article
- Overview of the Germline and Expressed Repertoires of the TRB Genes inFrontiers in immunology · 2018Article
- A comprehensive analysis of the germline and expressed TCR repertoire in White Peking duck.Scientific reports · 2017Article
- An overview of the lagomorph immune system and its genetic diversity.Immunogenetics · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study identifies the genomic structure and the gene content of the T cell receptor beta (TRB) locus in the Oryctolagus cuniculus whole genome assembly. The rabbit locus spans less than 600 Kb and the general genomic organization is highly conserved with respect to other mammalian species. A pool of 74 TRB variable (TRBV) genes distributed in 24 subgroups are located upstream of two in tandem-aligned D-J-C gene clusters, each composed of one TRBD, six TRBJ genes, and one TRBC gene, followed by a single TRBV gene with an inverted transcriptional orientation. All TRB genes (functional, ORF, pseudogenes) of this paper have been approved by the IMGT/WHO-IUIS nomenclature committee. Additionally, five potentially functional protease serine (PRSS) trypsinogen or trypsinogen-like genes were identified: two in tandem PRSS-like genes, followed by two PRSS genes with unique traits, lie downstream of the TRBV1 gene and one PRSS gene is located about 400 Kb away downstream of the TRBV genes. Comparative and phylogenetic analyses revealed that multiple duplication events within a few subgroups have generated the germline repertoire of the rabbit TRBV genes, which is substantially larger than those described in humans, mice, and dogs, suggesting that a strong evolutionary pressure has selected the development of a species-specific TRBV repertoire. Hence, the genomic organization of the TRB locus in the genomes appears to be the result of a balance between the maintenance of a core-number of genes essential for the immunological performances and the requirement of newly arisen genes.
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