ReviewJournal of chemical ecology2014
Potential ecological roles of artemisinin produced by Artemisia annua L.
Review in Journal of chemical ecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Host genotype and edaphic factors shaped bacterial communities associated with native and endemic medicinal Artemisia species in arid environment.Environmental microbiome · 2026Article
- Phytochemical Composition of Clonally PropagatedMolecules (Basel, Switzerland) · 2026Article
- Antifungal Activity and Biochemical Mechanisms of Artemisinin Against the PhytopathogenInternational journal of molecular sciences · 2026Article
- EndophyticPlants (Basel, Switzerland) · 2025Article
- Bio Prospecting of Endophytes and PGPRs in Artemisinin Production for the Socio-economic Advancement.Current microbiology · 2023Review
- Anti-Mitochondrial and Insecticidal Effects of Artemisinin againstInternational journal of molecular sciences · 2023Article
- Novel and holistic approaches are required to realize allelopathic potential for weed management.Ecology and evolution · 2023Review
- Heterogeneous nutrient supply modulates root exudation and accumulation of medicinally valuable compounds inFrontiers in plant science · 2023Article
- Secondary Metabolites fromMolecules (Basel, Switzerland) · 2021Review
- Review: Allelochemicals as multi-kingdom plant defence compounds: towards an integrated approach.Pest management science · 2021Review
- Proving the Mode of Action of Phytotoxic Phytochemicals.Plants (Basel, Switzerland) · 2020Review
- Endophytic Fungi in Species ofJournal of fungi (Basel, Switzerland) · 2018Review
- Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study ofFrontiers in plant science · 2017Article
- Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Invasive swallow-worts: an allelopathic role for -(-) antofine remains unclear.Journal of chemical ecology · 2015Article
- Anti-adipogenic effect of Artemisia annua in diet-induced-obesity mice model.Journal of veterinary science · 2015Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artemisia annua L. (annual wormwood, Asteraceae) and its secondary metabolite artemisinin, a unique sesquiterpene lactone with an endoperoxide bridge, has gained much attention due to its antimalarial properties. Artemisinin has a complex structure that requires a significant amount of energy for the plant to synthesize. So, what are the benefits to A. annua of producing this unique compound, and what is the ecological role of artemisinin? This review addresses these questions, discussing evidence of the potential utility of artemisinin in protecting the plant from insects and other herbivores, as well as pathogens and competing plant species. Abiotic factors affecting the artemisinin production, as well as mechanisms of artemisinin release to the surroundings also are discussed, and new data are provided on the toxicity of artemisinin towards soil and aquatic organisms. The antifungal and antibacterial effects reported are not very pronounced. Several studies have reported that extracts of A. annua have insecticidal effects, though few studies have proven that artemisinin could be the single compound responsible for the observed effects. However, the pathogen(s) or insect(s) that may have provided the selection pressure for the evolution of artemisinin synthesis may not have been represented in the research thus far conducted. The relatively high level of phytotoxicity of artemisinin in soil indicates that plant/plant allelopathy could be a beneficial function of artemisinin to the producing plant. The release routes of artemisinin (movement from roots and wash off from leaf surfaces) from A. annua to the soil support the rationale for allelopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.