Evidence map›Paper›PMID 24500611›Full record

Trial reportBMJ open2014

Effect of a 6-month vegan low-carbohydrate ('Eco-Atkins') diet on cardiovascular risk factors and body weight in hyperlipidaemic adults: a randomised controlled trial.

David J A Jenkins, Julia M W Wong, Cyril W C Kendall, Amin Esfahani, Vivian W Y Ng, Tracy C K Leong, Dorothea A Faulkner, Ed Vidgen, Gregory Paul, Ratna Mukherjea and 2 more

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 15 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00256516 phase2completednot on this map

Low Carbohydrate Portfolio or "Eco-Atkins" Diet

TypeinterventionalSponsorUniversity of TorontoRan2005 to 2006Enrolled30ConditionsHypercholesterolemia, Cardiovascular DiseasesArmsEco-Atkins diet (high vegetable protein and vegetable fat), NCEP diet
NCT02245399 nacompletednot on this map

Canola Enriched Mediterranean Type Weight Loss Diet in Type 2 Diabetes

TypeinterventionalSponsorUnity Health TorontoRan2014 to 2017Enrolled164ConditionsType 2 Diabetes, Obesity, Overweight, Cardiovascular DiseasesArmsA canola oil enriched mediterranean diet, A high wheat fiber diet
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 15 syntheses or guidelines pooled it, 104 citations in OpenAlex.

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  8. Effects of vegan diets on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

David J A JenkinsDepartment of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Julia M W Wong
Cyril W C Kendall
Amin Esfahani
Vivian W Y Ng
Tracy C K Leong
Dorothea A Faulkner
Ed Vidgen
Gregory Paul
Ratna Mukherjea
Elaine S Krul
William Singer
University of Toronto · CASt. Michael's Hospital · CAHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLow-carbohydrate diets may be useful for weight loss. Diets high in vegetable proteins and oils may reduce the risk of coronary heart disease. The main objective was to determine the longer term effect of a diet that was both low-carbohydrate and plant-based on weight loss and low-density lipoprotein cholesterol (LDL-C). DESIGN, SETTING,

participantsA parallel design study of 39 overweight hyperlipidaemic men and postmenopausal women conducted at a Canadian university-affiliated hospital nutrition research centre from April 2005 to November 2006.

interventionParticipants were advised to consume either a low-carbohydrate vegan diet or a high-carbohydrate lacto-ovo vegetarian diet for 6 months after completing 1-month metabolic (all foods provided) versions of these diets. The prescribed macronutrient intakes for the low-carbohydrate and high-carbohydrate diets were: 26% and 58% of energy from carbohydrate, 31% and 16% from protein and 43% and 25% from fat, respectively. PRIMARY OUTCOME: Change in body weight.

results23 participants (50% test, 68% control) completed the 6-month ad libitum study. The approximate 4 kg weight loss on the metabolic study was increased to -6.9 kg on low-carbohydrate and -5.8 kg on high-carbohydrate 6-month ad libitum treatments (treatment difference (95% CI) -1.1 kg (-2.1 to 0.0), p=0.047). The relative LDL-C and triglyceride reductions were also greater on the low-carbohydrate treatment (treatment difference (95% CI) -0.49 mmol/L (-0.70 to -0.28), p<0.001 and -0.34 mmol/L (-0.57 to -0.11), p=0.005, respectively), as were the total cholesterol:HDL-C and apolipoprotein B:A1 ratios (-0.57 (-0.83, -0.32), p<0.001 and -0.05 (-0.09, -0.02), p=0.003, respectively).

conclusionsA self-selected low-carbohydrate vegan diet, containing increased protein and fat from gluten and soy products, nuts and vegetable oils, had lipid lowering advantages over a high-carbohydrate, low-fat weight loss diet, thus improving heart disease risk factors.

trial registrationclinicaltrials.gov (http://www.clinicaltrials.gov/), #NCT00256516.

Indexed as

Body WeightDiet, Carbohydrate-RestrictedVegansAdultCardiovascular DiseasesFemaleHumansHyperlipidemiasMaleRisk FactorsTreatment OutcomeDietHyperlipidemiaWeight Loss

Identifiers

PMID24500611
PMCPMC3918974
OpenAlexW2096994865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.