ArticleParasitology research2014
A penta-substituted pyridine alkaloid from the rhizome of Jatropha elliptica (Pohl) Muell. Arg. is active against Schistosoma mansoni and Biomphalaria glabrata.
Article in Parasitology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 38 citations in OpenAlex.
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- Phytochemical Characterization and In Vitro Anti-Inflammatory Evaluation in RAW 264.7 Cells ofPlants (Basel, Switzerland) · 2023Article
- An Inventory of Anthelmintic Plants across the Globe.Pathogens (Basel, Switzerland) · 2023Review
- Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana.Journal of parasitology research · 2023Article
- Algal-Derived Halogenated Sesquiterpenes fromMarine drugs · 2022Article
- Computer-Assisted Discovery of Alkaloids with Schistosomicidal Activity.Current issues in molecular biology · 2022Article
- Article
- Effect of methyl gallate on immune response of Biomphalaria alexandrina (Ehrenberg, 1831) snails to infection with Schistosoma mansoni (Sambon, 1907).Parasitology research · 2021Article
- Molluscicidal and parasiticidal activities of Eryngium triquetrum essential oil on Schistosoma mansoni and its intermediate snail host Biomphalaria glabrata, a double impact.Parasites & vectors · 2020Article
- Data set of the toxic effects of divaricatic acid depside onData in brief · 2018Article
- Barbatic Acid Offers a New Possibility for Control of Biomphalaria Glabrata and Schistosomiasis.Molecules (Basel, Switzerland) · 2017Article
- ULTRASTRUCTURAL CHANGES IN Schistosoma mansoni MALE WORMS AFTER in vitro INCUBATION WITH THE ESSENTIAL OIL OF Mentha x villosa Huds.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Article
- Natural products as leads in schistosome drug discovery.Molecules (Basel, Switzerland) · 2015Article
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6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Jatropha elliptica is a shrub distributed throughout the north and west of Brazil and reputedly possesses a wide range of therapeutical properties. The roots of this plant possess molluscicidal activity and contain terpenoids, coumarin, lignoid, steroids and alkaloid. In the present study, we assessed the schistosomicidal, miracicidal and cercaricidal activities (against Schistosoma mansoni) and molluscicidal activities (against adults and egg masses of Biomphalaria glabrata) of the alkaloid diethyl 4-phenyl-2,6-dimethyl-3,5-pyridinedicarboxylate, isolated from the ethanol extract of the rhizome of J. elliptica, have been determined. The alkaloid was 100% lethal to adult schistosomes within 4 days at a concentration of 50 μg/mL. Alterations were observed in the schistosome tegument occasioned by treatment with the alkaloid, such as formation of vesicles and vacuolisation. The extent of tegumental damage of the worm was proportional to the time of incubation and to the concentration of compound. The alkaloid also exhibited a potent cercaricidal activity (LC100 = 2 μg/mL); it was totally ineffective against miracicidal forms of the parasite. Moreover, the alkaloid presented strong activity against adult snails (LC90 = 36.43 μg/mL) but was inactive against their egg masses. It is observed then the potential of this compound for the development of new therapies for the treatment of schistosomiasis.
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