ArticleJournal of biomedical optics2014
Tear film measurement by optical reflectometry technique.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Recent Progress on Optical Tomographic Technology for Measurements and Inspections of Film Structures.Micromachines · 2022Review
- Characterization of the thickness of the Tear Film Lipid Layer in Meibomian Gland Dysfunction using high resolution optical microscopy.The ocular surface · 2022Article
- 650 GHz imaging as alignment verification for millimeter wave corneal reflectometry.IEEE transactions on terahertz science and technology · 2022Article
- Validation of a new objective method to assess lipid layer thickness without the need of an interferometer.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Continuous In-Line Chromium Coating Thickness Measurement Methodologies: An Investigation of Current and Potential Technology.Sensors (Basel, Switzerland) · 2021Review
- Interactions of Meibum and Tears with Mucomimetic Polymers: A Hint towards the Interplay between the Layers of the Tear Film.International journal of molecular sciences · 2021Article
- Laser-induced corneal injury: validation of a computer model to predict thresholds.Biomedical optics express · 2021Article
- Spectroscopic Optical Coherence Tomography for Thin Layer and Foil Measurements.Sensors (Basel, Switzerland) · 2020Article
- In vivo thickness measurement of the lipid layer and the overall tear film by interferometry.Optics letters · 2019Article
- Interaction of ceramides and tear lipocalin.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2018Article
- Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy.BMC ophthalmology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Evaluation of tear film is performed by an optical reflectometer system with alignment guided by a galvanometer scanner. The reflectometer system utilizes optical fibers to deliver illumination light to the tear film and collect the film reflectance as a function of wavelength. Film thickness is determined by best fitting the reflectance-wavelength curve. The spectral reflectance acquisition time is 15 ms, fast enough for detecting film thickness changes. Fast beam alignment of 1 s is achieved by the galvanometer scanner. The reflectometer was first used to evaluate artificial tear film on a model eye with and without a contact lens. The film thickness and thinning rate have been successfully quantified with the minimum measured thickness of about 0.3 μm. Tear films in human eyes, with and without a contact lens, have also been evaluated. A high-contrast spectral reflectance signal from the precontact lens tear film is clearly observed, and the thinning dynamics have been easily recorded from 3.69 to 1.31 μm with lipid layer thickness variation in the range of 41 to 67 nm. The accuracy of the measurement is better than ±0.58% of the film thickness at an estimated tear film refractive index error of ±0.001. The fiber-based reflectometer system is compact and easy to handle.
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Registered trials
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