Evidence map›Paper›PMID 24500429›Full record

ReviewNature structural & molecular biology2014

Transcriptional control of a whole chromosome: emerging models for dosage compensation.

Francesco Ferrari, Artyom A Alekseyenko, Peter J Park, Mitzi I Kuroda

Open access · greenAbstract readReview
In one paragraph

Review in Nature structural & molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Review
  3. N-terminus ofeLife · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Dosage Compensation inInternational journal of molecular sciences · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Biological Function of Long Non-coding RNA (LncRNA) Xist.Frontiers in cell and developmental biology · 2021
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Francesco FerrariCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.
Artyom A Alekseyenko1] Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA. [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Peter J Park1] Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Mitzi I Kuroda1] Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA. [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USHarvard University · US

Funding

Molecular Genetics of Dosage Compensation in DrosophilaR37GM045744 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KURODA, MITZI I · 2004 to 2013
$3.7M
MOLECULAR GENETICS OF DOSAGE COMPENSATION IN DROSOPHILAR01GM045744 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KURODA, MITZI I · 1991 to 2017
$2.3M
NIGMS NIH HHS GM45744NIGMS NIH HHS R01 GM045744NIGMS NIH HHS R37 GM045744
6 · The paper itself

Abstract

Males and females of many animal species differ in their sex-chromosome karyotype, and this creates imbalances between X-chromosome and autosomal gene products that require compensation. Although distinct molecular mechanisms have evolved in three highly studied systems, they all achieve coordinate regulation of an entire chromosome by differential RNA-polymerase occupancy at X-linked genes. High-throughput genome-wide methods have been pivotal in driving the latest progress in the field. Here we review the emerging models for dosage compensation in mammals, flies and nematodes, with a focus on mechanisms affecting RNA polymerase II activity on the X chromosome.

Indexed as

Dosage Compensation, GeneticGene Expression RegulationModels, GeneticAnimalsCaenorhabditis elegansChromosomesDrosophila melanogasterGene SilencingGenomicsMammalsX Chromosome Inactivation

Identifiers

PMID24500429
PMCPMC4342042
OpenAlexW2014759458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.