ArticleScience translational medicine2014
Restoring natural sensory feedback in real-time bidirectional hand prostheses.
Article in Science translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 323 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peripheral Nerve Stimulation and Spinal Cord Stimulation in Patients With Phantom Limb Pain After Upper Limb Amputation for Phantom Limb Pain Suppression and Development of the Biomarkers
Peripheral Nerve and Spinal Cord Stimulation in Patients With Pain Syndrome as a Result of Lower Limb Amputation in Order to Relieve Pain Syndrome and Develop Phantom Pain Biomarkers
Who cites it
323 citing papers in PubMed, 2 syntheses or guidelines pooled it, 988 citations in OpenAlex.
- Artificial referred sensation in upper and lower limb prosthesis users: a systematic review.Journal of neural engineering · 2022Pooled it
- Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics.Frontiers in bioengineering and biotechnology · 2021Pooled it
- First-in-human implementation of a bidirectional somatosensory neuroprosthetic system with wireless communication.Journal of neuroengineering and rehabilitation · 2025Trial
- Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills.Nature human behaviour · 2024Trial
- Characterization of multi-channel intraneural stimulation in transradial amputees.Scientific reports · 2019Trial
- Neural Interfaces for Bidirectional Sensory Restoration in Limb Prostheses: Current Evidence and Clinical Translation.Journal of clinical medicine · 2026Review
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Three-Dimensional Interconnect Technologies for Advanced Flexible Electronics.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Functional Somatotopy of Lumbar Dorsal Rootlets and its Role in Selective Recruitment via Lateral Spinal Cord Stimulation.bioRxiv : the preprint server for biology · 2026Article
- logLIRA: a method for reliable suppression of electrical stimulation artifacts enabling short-latency neural response recovery.Journal of neural engineering · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Transforming healthcare through in-body bioelectronic systems.Nature communications · 2026Review
- A Cloud-Aware Scalable Architecture for Distributed Edge-Enabled BCI Biosensor System.Biosensors · 2026Article
- Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury.Nature biomedical engineering · 2026Article
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- On the reliability of non-hermetically encapsulated ceramic printed circuit boards as bridging elements in neural implants.Frontiers in neuroscience · 2026Article
- Using a single penetrating interfascicular electrode to improve spatial selectivity of an extraneural polymeric cuff array.Bioelectronic medicine · 2025Article
- Shared human-machine control of an intelligent bionic hand improves grasping and decreases cognitive burden for transradial amputees.Nature communications · 2025Article
- Differences and Commonalities of Electrical Stimulation Paradigms After Central Paralysis and Amputation.Artificial organs · 2025Review
- Toward Natural Limb Function: A New Era in Prosthetic Innovation.Annals of neurology · 2025Review
263 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hand loss is a highly disabling event that markedly affects the quality of life. To achieve a close to natural replacement for the lost hand, the user should be provided with the rich sensations that we naturally perceive when grasping or manipulating an object. Ideal bidirectional hand prostheses should involve both a reliable decoding of the user's intentions and the delivery of nearly "natural" sensory feedback through remnant afferent pathways, simultaneously and in real time. However, current hand prostheses fail to achieve these requirements, particularly because they lack any sensory feedback. We show that by stimulating the median and ulnar nerve fascicles using transversal multichannel intrafascicular electrodes, according to the information provided by the artificial sensors from a hand prosthesis, physiologically appropriate (near-natural) sensory information can be provided to an amputee during the real-time decoding of different grasping tasks to control a dexterous hand prosthesis. This feedback enabled the participant to effectively modulate the grasping force of the prosthesis with no visual or auditory feedback. Three different force levels were distinguished and consistently used by the subject. The results also demonstrate that a high complexity of perception can be obtained, allowing the subject to identify the stiffness and shape of three different objects by exploiting different characteristics of the elicited sensations. This approach could improve the efficacy and "life-like" quality of hand prostheses, resulting in a keystone strategy for the near-natural replacement of missing hands.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.