ArticleEuropean journal of pediatrics2014
Serum hepcidin levels and iron metabolism in obese children with and without fatty liver: case-control study.
Article in European journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Association of serum ferritin with non-alcoholic fatty liver disease: a meta-analysis.Lipids in health and disease · 2017Pooled it
- Hepcidin and inflammation associated with iron deficiency in childhood obesity - A systematic review.Jornal de pediatriaPooled it
- The convergent roles of metabolic dysfunction, alcohol, and iron in steatotic liver disease: a review.Bioscience reports · 2026Review
- Association of whole blood copper, zinc, calcium, magnesium, and iron with non-alcoholic fatty liver disease in overweight and obese children.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis.Cell metabolism · 2022Article
- Cord blood levels of interleukin-10 decrease in neonates with increased birth weight: novel implications of the cytokine network in early obesity.European journal of pediatrics · 2021Article
- Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity.Frontiers in endocrinology · 2020Article
- Iron and liver fibrosis: Mechanistic and clinical aspects.World journal of gastroenterology · 2019Review
- Low hepcidin in liver fibrosis and cirrhosis; a tale of progressive disorder and a case for a new biochemical marker.Molecular medicine (Cambridge, Mass.) · 2018Review
- Predictive Role of Interleukin-18 in Liver Steatosis in Obese Children.Canadian journal of gastroenterology & hepatology · 2018Article
- Non-alcoholic fatty liver disease: an update on diagnosis.Clujul medical (1957) · 2018Review
- Uncoupled iron homeostasis in type 2 diabetes mellitus.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Fat content, fatty acid pattern and iron content in livers of turkeys with hepatic lipidosis.Lipids in health and disease · 2017Article
- Article
- A review of iron studies in overweight and obese children and adolescents: a double burden in the young?European journal of nutrition · 2016Review
- Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD.International journal of molecular sciences · 2016Review
- The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease.BioMed research international · 2015Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledHepcidin is a regulator of iron balance that is increased in obesity. It reduces the absorption of iron, reduces the transfer of iron from macrophages to the plasma and/or prevents mobilisation of stored iron. Obese patients with non-alcoholic fatty liver disease (NAFLD) demonstrate adipokine and cytokine release promoting inflammatory response. We aimed to analyse the hepcidin levels and iron metabolism in obese children with and without NAFLD and non-obese healthy controls. The study population consisted of 110 children aged 7-18 years in three groups: 50 obese patients without NAFLD, 30 obese patients with NAFLD, and 30 non-obese healthy controls. Serum hepcidin, ferritin, and iron levels, iron-binding capacity, lipid profile, and liver function tests were measured, and hepatic ultrasonography was performed in all participants. Obese patients' white blood cell counts, total cholesterol, triglyceride levels, and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher than those of the control group. Iron-binding capacity was significantly higher in obese patients without NAFLD compared with obese patients with NAFLD (p = 0.002). Hepcidin levels were not significantly different between obese patients and the control group. However, hepcidin levels in obese patients with NAFLD were significantly higher than those in obese patients without NAFLD (p < 0.001).
conclusionsHepcidin levels were significantly higher in obese children with NAFLD than those without NAFLD. Obese children with NAFLD should receive attention regarding iron metabolism disorders. Serum hepcidin could be a marker of iron metabolism status and NAFLD in these groups of patients.
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