Evidence map›Paper›PMID 24499735›Full record

ArticleThe Journal of investigative dermatology2014

Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice.

Oludotun Adeyo, Bernard B Allan, Richard H Barnes, Chris N Goulbourne, Angelica Tatar, Yiping Tu, Lorraine C Young, Michael M Weinstein, Peter Tontonoz, Loren G Fong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  4. Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models of Hereditary Palmoplantar Keratoderma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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  12. Evolution and Medical Significance of LU Domain-Containing Proteins.International journal of molecular sciences · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Oludotun AdeyoDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Bernard B AllanDepartment of Molecular Biology, Genentech, South San Francisco, California, USA.
Richard H BarnesDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Chris N GoulbourneDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Angelica TatarDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Yiping TuDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Lorraine C YoungDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Michael M WeinsteinDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Peter TontonozDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Howard Hughes Medical Institute, South San Francisco, California, USA.
Loren G FongDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Anne P BeigneuxDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. Electronic address: abeigneux@mednet.ucla.edu.
Stephen G YoungDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Departments of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. Electronic address: sgyoung@mednet.ucla.edu.
University of California, Los Angeles · USHoward Hughes Medical Institute · US

Funding

The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2008 to 2018
$23.3M
NHLBI NIH HHS P01 HL090553
6 · The paper itself

Abstract

Mutations in SLURP1 cause mal de Meleda, a rare palmoplantar keratoderma (PPK). SLURP1 is a secreted protein that is expressed highly in keratinocytes but has also been identified elsewhere (e.g., spinal cord neurons). Here, we examined Slurp1-deficient mice (Slurp1(-/-)) created by replacing exon 2 with β-gal and neo cassettes. Slurp1(-/-) mice developed severe PPK characterized by increased keratinocyte proliferation, an accumulation of lipid droplets in the stratum corneum, and a water barrier defect. In addition, Slurp1(-/-) mice exhibited reduced adiposity, protection from obesity on a high-fat diet, low plasma lipid levels, and a neuromuscular abnormality (hind-limb clasping). Initially, it was unclear whether the metabolic and neuromuscular phenotypes were due to Slurp1 deficiency, because we found that the targeted Slurp1 mutation reduced the expression of several neighboring genes (e.g., Slurp2, Lypd2). We therefore created a new line of knockout mice (Slurp1X(-/-) mice) with a simple nonsense mutation in exon 2. The Slurp1X mutation did not reduce the expression of adjacent genes, but Slurp1X(-/-) mice exhibited all of the phenotypes observed in the original line of knockout mice. Thus, Slurp1 deficiency in mice elicits metabolic and neuromuscular abnormalities in addition to PPK.

Indexed as

AllelesAnimalsAntigens, LyBody WeightCodon, NonsenseEpidermisExonsFemaleGenotypeKeratoderma, PalmoplantarLipidsMaleMiceMice, KnockoutNeuromuscular DiseasesPhenotypeAntigens, LyCodon, NonsenseLipidsLy6 protein, mouseSLURP-1 protein, mouseUrokinase-Type Plasminogen ActivatorWater

Identifiers

PMID24499735
PMCPMC4214150
OpenAlexW2002420931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.