Observational studyCritical care (London, England)2013
Muscle ultrasound for early assessment of critical illness neuromyopathy in severe sepsis.
Observational study in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06697470 (Cross-sectional Study on the Variation of Muscle Thickness and Subcutaneous Tissues by Ultrasound and Bioelectrical Impedance in Association with the Fluid Balance of Patients in Intensive Care), which is not on this map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cross-sectional Study on the Variation of Muscle Thickness and Subcutaneous Tissues by Ultrasound and Bioelectrical Impedance in Association with the Fluid Balance of Patients in Intensive Care
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Quantitative neuromuscular ultrasound in intensive care unit-acquired weakness: A systematic review.Muscle & nerve · 2015Pooled it
- Exercise rehabilitation following intensive care unit discharge for recovery from critical illness.The Cochrane database of systematic reviews · 2015Pooled it
- Assessment of impairment and activity limitations in the critically ill: a systematic review of measurement instruments and their clinimetric properties.Intensive care medicine · 2015Pooled it
- Dizziness, Lower Limb Weakness, and Falls in COPD: A Prospective Longitudinal Pilot Study Using Monthly Home Diaries.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Observational
- Early Measurement of Quadriceps Response to Neuromuscular Electrical Stimulation to Identify Future ICU-Acquired Weakness.Critical care medicine · 2026Observational
- Muscle matters: Transforming the care of intensive care unit acquired sarcopenia and myosteatosis.World journal of clinical cases · 2025Review
- Effect of standard- versus high-protein enteral feeding on rectus femoris muscle mass in mechanically ventilated traumatic brain injury: prospective randomized study.Acute and critical care · 2025Article
- The role of bedside ultrasound in nutritional monitoring: an observational study on the correlation between quadriceps muscle layer thickness and prealbumin in ICU patients.BMC anesthesiology · 2025Observational
- Persistent neuromuscular disorders associated with changes in tibialis anterior and gastrocnemius lateralis muscle architecture in long-covid: an observational longitudinal study.Scientific reports · 2025Observational
- Artificial Intelligence-Assisted Muscular Ultrasonography for Assessing Inflammation and Muscle Mass in Patients at Risk of Malnutrition.Nutrients · 2025Observational
- Effect of High Protein Normocaloric Nutrition on Skeletal Muscle Wasting in Critically Ill Mechanically Ventilated Patients: A Randomized Double-blind Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Article
- Assessment of quadriceps muscle mass by ultrasound in the postoperative period of cardiac surgery.The ultrasound journal · 2024Article
- A Predictive Nomogram for Intensive Care-Acquired Weakness after Cardiopulmonary Bypass.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2024Article
- Feasibility of anterior temporalis muscle ultrasound for assessing muscle wasting in ICU: a prospective cohort study.Journal of ultrasound · 2023Article
- [Intensive care unit-acquired weakness-Diagnostic value of neuromuscular ultrasound].Die Anaesthesiologie · 2023Review
- Evaluation of Changes in Quadriceps Femoris Muscle in Critically III Children Using Ultrasonography.Indian journal of pediatrics · 2023Article
- Comparison of Different Ultrasound Methods to Assess Changes in Muscle Mass in Critically ill Patients.Journal of intensive care medicine · 2023Observational
- Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions.Medicina (Kaunas, Lithuania) · 2023Review
- Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors: a case-control study.BMC medical imaging · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMuscle ultrasound is emerging as a promising tool in the diagnosis of neuromuscular diseases. The current observational study evaluates the usefulness of muscle ultrasound in patients with severe sepsis for assessment of critical illness polyneuropathy and myopathy (CINM) in the intensive care unit.
methods28 patients with either septic shock or severe sepsis underwent clinical neurological examinations, muscle ultrasound, and nerve conduction studies on days 4 and 14 after onset of sepsis. 26 healthy controls of comparable age underwent clinical neurological evaluation and muscle ultrasound only.
results26 of the 28 patients exhibited classic electrophysiological characteristics of CINM, and all showed typical clinical signs. Ultrasonic echogenicity of muscles was graded semiquantitatively and fasciculations were evaluated in muscles of proximal and distal arms and legs. 75% of patients showed a mean echotexture greater than 1.5, which was the maximal value found in the control group. A significant difference in mean muscle echotexture between patients and controls was found at day 4 and day 14 (both p < 0.001). In addition, from day 4 to day 14, the mean grades of muscle echotexture increased in the patient group, although the values did not reach significance levels (p = 0.085). Controls revealed the lowest number of fasciculations. In the patients group, fasciculations were detected in more muscular regions (lower and upper arm and leg) in comparison to controls (p = 0.08 at day 4 and p = 0.002 at day 14).
conclusionsMuscle ultrasound represents an easily applicable, non-invasive diagnostic tool which adds to neurophysiological testing information regarding morphological changes of muscles early in the course of sepsis. Muscle ultrasound could be useful for screening purposes prior to subjecting patients to more invasive techniques such as electromyography and/or muscle biopsy.
trial registrationGerman Clinical Trials Register, DRKS-ID: DRKS00000642.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.