ArticleParasites & vectors2013
Lymphatic filariasis in Luangwa District, South-East Zambia.
Article in Parasites & vectors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 21 citations in OpenAlex.
- Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination.Tropical medicine and infectious disease · 2024Review
- Prevalence of elephantiasis, an overlooked disease in Southern Africa: a comprehensive review.The journal of venomous animals and toxins including tropical diseases · 2024Review
- Lymphatic Filariasis Elimination Status:Tropical medicine and infectious disease · 2023Article
- Unlocking Trust in Community Health Systems: Lessons From the Lymphatic Filariasis Morbidity Management and Disability Prevention Pilot Project in Luangwa District, Zambia.International journal of health policy and management · 2022Article
- How community engagement strategies shape participation in mass drug administration programmes for lymphatic filariasis: The case of Luangwa District, Zambia.PLoS neglected tropical diseases · 2019Article
- Mapping and monitoring for a lymphatic filariasis elimination program: a systematic review.Research and reports in tropical medicine · 2019Review
- Use of Antibody Tools to Provide Serologic Evidence of Elimination of Lymphatic Filariasis in The Gambia.The American journal of tropical medicine and hygiene · 2018Article
- Significant decline in lymphatic filariasis associated with nationwide scale-up of insecticide-treated nets in Zambia.Parasite epidemiology and control · 2017Article
- Concordance between Plasma and Filter Paper Sampling Techniques for the Lymphatic Filariasis Bm14 Antibody ELISA.Tropical medicine and infectious disease · 2017Article
- Detecting and staging podoconiosis cases in North West Cameroon: positive predictive value of clinical screening of patients by community health workers and researchers.BMC public health · 2016Article
- Lymphatic filariasis in Peninsular Malaysia: a cross-sectional survey of the knowledge, attitudes, and practices of residents.Parasites & vectors · 2014Article
- Integrated mapping of lymphatic filariasis and podoconiosis: lessons learnt from Ethiopia.Parasites & vectors · 2014Article
- Mapping the geographical distribution of lymphatic filariasis in Zambia.PLoS neglected tropical diseases · 2014Article
- Performance of five food regimes on Anopheles gambiae senso stricto larval rearing to adult emergence in insectary.PloS one · 2014Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPast case reports and recent data from LF mapping surveys indicate that LF occurs in Zambia, but no studies have been carried out to document its epidemiology and health implications. The present study assessed infection, disease, transmission and human perception aspects of LF in an endemic area of Luangwa District, South-East Zambia, as a background for planning and implementation of control.
methodsTwo neighbouring rural communities were registered and a questionnaire survey undertaken. Clinical examination, and sampling of blood for circulating filarial antigens (CFA; marker of adult worm infection) and antibodies to Bm14 antigen (marker of exposure to transmission), were carried out during the daytime. Blood from CFA positive individuals was examined for microfilariae (mf) at night. Vector surveys were carried out in selected households, using light traps.
results985 individuals aged ≥ 1 year were registered. The CFA prevalence increased with age from 1.2% in age group 1-14 years to 20.6% in age group 50+ years (overall 8.6%). Wuchereria bancrofti mf were identified in 10.9% of CFA positive individuals (corresponding to a community prevalence of 0.9%). Prevalence and intensity of Bm14 antibodies were much higher in individuals ≥ 30 years than in younger individuals (57.2 vs. 19.3%; 0.594 vs. 0.241 OD-values). Elephantiasis and hydrocele were well known clinical manifestations in the area, but only one case of hydrocele was detected in the study population. Identified potential vectors were Anopheles funestus and An. gambiae.
conclusionThe study confirmed that LF was endemic in the study communities, but infection and disease prevalence was low. Several indications, including a marked recent decline in CFA prevalence, suggest that transmission in the area is on the decrease, perhaps because of intensive application of malaria control measures targeting the Anopheles vectors. It is recommended that mass drug administration is initiated to accelerate this positive trend of decline in LF transmission in the area.
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