Evidence map›Paper›PMID 24499349›Full record

ArticleBioconjugate chemistry2014

Synthesis of fluorophore-tagged xylosides that prime glycosaminoglycan chains.

Vy M Tran, Balagurunathan Kuberan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vy M TranDepartments of Medicinal Chemistry and †Bioengineering, University of Utah , Salt Lake City, Utah 84112, United States.
Balagurunathan Kuberan
University of Utah · US

Funding

Therapeutic assessment of synthetic heparin sulfates in transplantation modelsP01HL107152 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI DESAI, UMESH RAMANLAL · 2011 to 2017
$15.8M
Biophysics and Biomechanics of the Semicircular CanalsR01DC006685 · NIDCD · UNIVERSITY OF UTAH · PI RABBITT, RICHARD D · 2005 to 2022
$6.8M
HEPARANOMICS: STRUCTURE-FUNCTION RELATIONSHIPSR01GM075168 · NIGMS · UNIVERSITY OF UTAH · PI BALAGURUNATHAN, KUBERAN · 2007 to 2011
$1.5M
NHLBI NIH HHS P01 HL107152NHLBI NIH HHS P01HL107152NIDCD NIH HHS R01 DC006685NIDCD NIH HHS R01DC006685NIGMS NIH HHS R01 GM075168NIGMS NIH HHS R01GM075168
6 · The paper itself

Abstract

Biosynthesis and functions of glycosaminoglycan (GAG) chains are complex and remain elusive. To better understand the factors that regulate the biosynthesis and functions, fluorophore-tagged xylosides carrying two different linkages between fluorophore and xylose residue were synthesized and evaluated for their ability to prime GAG chains such as heparan sulfate (HS), chondroitin sulfate (CS), and dermatan sulfate (DS) in various cell lines. These in vitro studies resulted in the identification of fluorophore-tagged xylosides that prime high molecular weight GAG chains. Primed GAG chains carrying a fluorophore group has several advantages for studying the factors that regulate the biosynthesis, analyzing intact fine structures at low detection limits, and setting the stage for studying structure-function relations of GAG chains of cellular origin.

Indexed as

AnimalsCHO CellsCricetinaeCricetulusFluorescent DyesGlycosaminoglycansGlycosidesMagnetic Resonance SpectroscopySpectrometry, Mass, Electrospray IonizationFluorescent DyesGlycosaminoglycansGlycosidesxylosides

Identifiers

PMID24499349
PMCPMC3983138
OpenAlexW2073211348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.