ArticleMolecular cancer2014
The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma.
Article in Molecular cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Prognostic impact of dynamic changes of type I melanoma antigen gene proteins CT7 (Frontiers in medicine · 2025Article
- MAGE-C3 promotes cancer metastasis by inducing epithelial-mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma.Cancer communications (London, England) · 2021Article
- MAGE genes: Prognostic indicators in AL amyloidosis patients.Journal of cellular and molecular medicine · 2019Article
- Monoclonal gammopathy of undetermined significance in Chinese population: A prospective epidemiological study.Hematological oncology · 2019Article
- Article
- Combined cancer testis antigens enhanced prediction accuracy for prognosis of patients with hepatocellular carcinoma.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in this disease are not fully understood. This study measured the expression levels of four CT antigen genes in Chinese patients with MM and explored their clinical implications.
methodsReal-time quantitative polymerase chain reaction (qPCR) was used to quantify the expression of MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 mRNA in 256 bone marrow samples from 144 MM patients.
resultsIn the newly diagnosed patients, the positive expression rates were 88.5% for MAGE-C1/CT7, 82.1% for MAGE-C2/CT10, 76.9% for MAGE-A3 and 25.6% for SSX-2. The expression levels and the number of co-expressed CT antigens correlated significantly with several clinical indicators, including the percentage of plasma cells infiltrating the bone marrow, abnormal chromosome karyotypes and the clinical course.
conclusionMAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 expression levels provide potentially effective clinical indicators for the auxiliary diagnosis and monitoring of treatment efficacy in MM.
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