ArticleImmunity & ageing : I & A2013
Association of a common TLR-6 polymorphism with coronary artery disease - implications for healthy ageing?
Article in Immunity & ageing : I & A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- The predictive value of the neutrophil/platelet ratio on in-hospital adverse events and long-term prognosis in patients with coronary artery disease after percutaneous coronary intervention and its possible internal mechanism.Molecular and cellular biochemistry · 2024Article
- In silico analysis reveals interrelation of enriched pathways and genes in type 1 diabetes.Immunogenetics · 2020Article
- Review
- The Association of rs1898830 inJournal of cardiovascular development and disease · 2020Article
- Microbial modulation of cardiovascular disease.Nature reviews. Microbiology · 2018Review
- Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein 180L Single-Nucleotide Polymorphism Is Associated With Susceptibility to Recurrent Pneumococcal Lower Respiratory Tract Infections in Children.Frontiers in immunology · 2018Article
- Association of TLR and TREM-1 gene polymorphisms with atherosclerosis severity in a Russian population.Meta gene · 2016Article
- Genetic predisposition of variants in TLR2 and its co-receptors to severe malaria in Odisha, India.Immunologic research · 2016Article
- TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians - A cohort study.Immunity & ageing : I & A · 2016Article
- TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion.European heart journal · 2015Article
- Polymorphisms in Toll-like receptor genes are associated with vitiligo.Frontiers in genetics · 2015Article
- Less functional variants of TLR-1/-6/-10 genes are associated with age.Immunity & ageing : I & A · 2015Article
- Association of Toll-like receptor polymorphisms with HIV status in North Americans.Genes and immunity · 2014Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pro-inflammatory status of the elderly triggers most of the age-related diseases such as cancer and atherosclerosis. Atherosclerosis, the leading cause world wide of morbidity and death, is an inflammatory disease influenced by life-style and genetic host factors. Stimuli such as oxLDL or microbial ligands have been proposed to trigger inflammation leading to atherosclerosis. It has recently been shown that oxLDL activates immune cells via the Toll-like receptor (TLR) 4/6 complex. Several common single nucleotide polymorphisms (SNPs) of the TLR system have been associated with atherosclerosis. To investigate the role of TLR-6 we analyzed the association of the TLR-6 SNP Pro249Ser with atherogenesis.
resultsGenotyping of two independent groups with CAD, as well as of healthy controls revealed a significant association of the homozygous genotype with a reduced risk for atherosclerosis (odds ratio: 0.69, 95% CI 0.51-0.95, P = 0.02). In addition, we found a trend towards an association with the risk of restenosis after transluminal coronary angioplasty (odds ratio: 0.53, 95% CI 0.24-1.16, P = 0.12). In addition, first evidence is presented that the frequency of this protective genotype increases in a healthy population with age. Taken together, our results define a role for TLR-6 and its genetic variations in modulating the inflammatory response leading to atherosclerosis.
conclusionsThese results may lead to a better risk stratification, and potentially to an improved prophylactic treatment of high-risk populations. Furthermore, the protective effect of this polymorphism may lead to an increase of this genotype in the healthy elderly and may therefore be a novel genetic marker for the well-being during aging.
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