ArticleImmunity & ageing : I & A2013
Age and menopause affect the expression of specific cytokines/chemokines in plasma and cervical lavage samples from female sex workers in Nairobi, Kenya.
Article in Immunity & ageing : I & A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Association between postmenopausal vulvovaginal discomfort, vaginal microbiota, and mucosal inflammation.American journal of obstetrics and gynecology · 2021Trial
- HIV-Associated Genital Immune Biomarkers in the Female Sex Worker Population: A Pilot Study.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- HPV and coronary diseases in menopausal women: an integrative review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Review
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- Effects of hormone replacement therapy on lens opacity, serum inflammatory cytokines, and antioxidant levels.Annals of medicine · 2021Article
- Sex Differences and COVID-19.Advances in experimental medicine and biology · 2021Article
- Low-Dose Acetylsalicylic Acid Reduces T Cell Immune Activation: Potential Implications for HIV Prevention.Frontiers in immunology · 2021Article
- Phylogenetic Analyses Comparing HIV Sequences from Plasma at Virologic Failure to Cervix Versus Blood Sequences from Antecedent Antiretroviral Therapy Suppression.AIDS research and human retroviruses · 2019Observational
- Human Papillomavirus and Coronary Artery Disease in Climacteric Women: Is There an Association?TheScientificWorldJournal · 2019Article
- The Cell Surface Markers Expression in Postmenopausal Women and Relation to Obesity and Bone Status.International journal of environmental research and public health · 2017Article
- Differences in age-specific HPV prevalence between self-collected and health personnel collected specimen in a cross-sectional study in Ghana.Infectious agents and cancer · 2017Article
- Human papillomavirus genotypes and HPV-16 variants distribution among Tunisian women with normal cytology and squamous intraepithelial lesions.Infectious agents and cancer · 2016Article
- Human papillomavirus infection and cervical dysplasia in female sex workers in Northeast China: an observational study.BMC public health · 2015Observational
- Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging of the immune system, known as immunosenescence, is associated with profound changes in both innate and adaptive immune responses, resulting in increased susceptibility to infection and a decreased ability to respond to vaccination. The purpose of this study was to investigate the effect of age and menopause on the expression of 22 different cytokines/chemokines in both plasma and cervical lavage samples from female sex-worker cohort from Nairobi, Kenya (age range 20-65).
resultsCytokine/chemokine levels were measured using a Miliplex multiplex assay (Millipore). We found that age positively correlated with MCP-1 (p = 0.0002) and IP-10 (p = 0.03) systemic cytokine expression, and that women over 50 expressed the highest levels of these cytokines, but also had elevated expression of MIG (ANOVA p = 0.0096) and MIP-3β(ANOVA p = 0.0434). We also found that IL-8 (p = 0.047) and sCD40L (p = 0.01) systemic expression negatively correlated with age. Further, MIG (p = 0.0081) and MCP-1 (p = 0.0157) were present at higher levels in post-menopausal women suggesting a potential estrogen dependant systemic regulation of these cytokines. In cervical lavage samples, age did not directly correlate with the expression of any of the tested cytokines/chemokines, however sIL-2Rα (ANOVA p = 0.0170) and IL-15 (ANOVA p = 0.0251)were significantly higher in women over 50. Menopause was shown to have a more profound effect on cytokine expression in the cervical mucosa with MIG (p = 0.0256), MIP-3α (p = 0.0245), IL-1β (p = 0.0261), IL-6 (p = 0.0462), IL-8 (p = 0.007), IP-10 (p = 0.0357) and MCP-1 (p = 0.0427) all significantly under-expressed in post-menopausal women.
conclusionsThis study demonstrates that aging and menopause-associated hormonal changes are associated with significant changes in systemic and mucosal cytokine/chemokine expression, which may have implications for the age-related decline in the ability to fight against infections.
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