ReviewPLoS neglected tropical diseases2014
Estimating the burden of Japanese encephalitis virus and other encephalitides in countries of the mekong region.
Review in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Review of the aetiologies of central nervous system infections in Vietnam.Frontiers in public health · 2024Pooled it
- Estimating the burden of scrub typhus: A systematic review.PLoS neglected tropical diseases · 2017Pooled it
- Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia.PloS one · 2018Trial
- Japanese encephalitis virus hijacks the host purine biosynthetic network to promote viral replication in neurons.PLoS pathogens · 2026Article
- Advances and Challenges in Vaccination and Therapeutic Strategies Against Japanese Encephalitis Virus.Pathogens (Basel, Switzerland) · 2025Review
- Effect of adjuvant treatment with Xiyanping injection on the prognosis of viral encephalitis in children: a multicenter retrospective study.Frontiers in pharmacology · 2025Article
- Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus.Journal of extracellular vesicles · 2025Article
- Sero-epidemiology and risk factor investigation for exposure to Japanese encephalitis virus in swine populations reared in climatically diverse regions of India.Tropical animal health and production · 2024Article
- Article
- Endogenous ZAP affects Zika virus RNA interactome.RNA biology · 2024Article
- Central nervous system infection in a pediatric population in West Java.PLoS neglected tropical diseases · 2023Article
- The spatio-temporal distribution of acute encephalitis syndrome and its association with climate and landcover in Vietnam.BMC infectious diseases · 2023Article
- Modelling the Potential Human Exposure to Japanese Encephalitis Virus (JEV) in Case of Introduction into Reunion Island.Transboundary and emerging diseases · 2023Article
- Japanese encephalitis virus persists in the human reproductive epithelium and porcine reproductive tissues.PLoS neglected tropical diseases · 2022Article
- Childhood encephalitis in the Greater Mekong region (the SouthEast Asia Encephalitis Project): a multicentre prospective study.The Lancet. Global health · 2022Observational
- Modelling Japanese encephalitis virus transmission dynamics and human exposure in a Cambodian rural multi-host system.PLoS neglected tropical diseases · 2022Article
- The Ecology and Evolution of Japanese Encephalitis Virus.Pathogens (Basel, Switzerland) · 2021Review
- Economic and disease burden of Japanese encephalitis in Zhejiang Province, 2013-2018.PLoS neglected tropical diseases · 2021Article
- Review
- Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China.Annals of global health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverse aetiologies of viral and bacterial encephalitis are widely recognized as significant yet neglected public health issues in the Mekong region. A robust analysis of the corresponding health burden is lacking. We retrieved 75 articles on encephalitis in the region published in English or in French from 1965 through 2011. Review of available data demonstrated that they are sparse and often derived from hospital-based studies with significant recruitment bias. Almost half (35 of 75) of articles were on Japanese encephalitis virus (JEV) alone or associated with dengue. In the Western Pacific region the WHO reported 30,000-50,000 annual JEV cases (15,000 deaths) between 1966 and 1996 and 4,633 cases (200 deaths) in 2008, a decline likely related to the introduction of JEV vaccination in China, Vietnam, or Thailand since the 1980s. Data on dengue, scrub typhus and rabies encephalitis, among other aetiologies, are also reviewed and discussed. Countries of the Mekong region are undergoing profound demographic, economic and ecological change. As the epidemiological aspects of Japanese encephalitis (JE) are transformed by vaccination in some countries, highly integrated expert collaborative research and objective data are needed to identify and prioritize the human health, animal health and economic burden due to JE and other pathogens associated with encephalitides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.