ArticlePloS one2014
Telomere length in peripheral blood leukocytes is associated with risk of colorectal cancer in Chinese population.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Association between telomere length and the risk of colorectal cancer: a meta-analysis of observational studies.BMC cancer · 2017Pooled it
- The association between telomere length and cancer risk in population studies.Scientific reports · 2016Pooled it
- A Randomized Controlled Trial to Increase Navy Bean or Rice Bran Consumption in Colorectal Cancer Survivors.Nutrition and cancerTrial
- Potential of hTERT mRNA for the management of advanced head and neck squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Risk Factors in Sporadic Early-Onset Colorectal Cancer, Current Evidence and Emerging Insights: A Systematic Review.Cancers · 2026Review
- Comparing Length and Telomere Expression at Oral Precancerous and Cancerous Stages.Iranian journal of pathology · 2024Article
- Association of Telomere Length with Colorectal Cancer Risk and Prognosis: A Systematic Review and Meta-Analysis.Cancers · 2023Review
- Pre-diagnostic telomere length and colorectal cancer risk.Cancer epidemiology · 2022Article
- Novel Prognostic Biomarkers in Metastatic and Locally Advanced Colorectal Cancer: Micronuclei Frequency and Telomerase Activity in Peripheral Blood Lymphocytes.Frontiers in oncology · 2021Article
- Telomere Maintenance Variants and Survival after Colorectal Cancer: Smoking- and Sex-Specific Associations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Genetic variations associated with telomere length affect the risk of gastric carcinoma.Medicine · 2020Article
- Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors.Cancers · 2020Article
- Association Between Leukocyte Telomere Length and Colorectal Cancer Risk in the Singapore Chinese Health Study.Clinical and translational gastroenterology · 2019Article
- Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study.BMC cancer · 2018Article
- Altered expression of telomere-associated genes in leukocytes among BRCA1 and BRCA2 carriers.Molecular carcinogenesis · 2018Article
- Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel.British journal of cancer · 2018Article
- Article
- Chromosome Abnormalities and Absolute Telomere Lengths of Leukocytes from Silk Weavers with Emphasis on Potential Genotoxicity and Mutagenicity of Silk DyesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Article
- Social-demographics, health behaviors, and telomere length in the Mexican American Mano a Mano Cohort.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman telomeres, tandem repeats of TTAGGG nucleotides at the ends of chromosomes, are essential for maintaining genomic integrity and stability. Results of previous epidemiologic studies about the association of telomere length with risk of colorectal cancer (CRC) have been conflicting.
methodsA case-control study was conducted in a Han population in Wuhan, central China. The relative telomere length (RTL) was measured in peripheral blood leukocytes (PBLs) using quantitative real-time polymerase chain reaction (PCR) in 628 CRC cases and 1,256 age and sex frequency matched cancer-free controls. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression models to evaluate the association between RTL and CRC risk.
resultsUsing median RTL in the controls as the cutoff, individuals with shorter RTL were associated with a significantly increased risk of CRC (adjusted OR = 1.27, 95%CI: 1.05-1.55). When participants were further categorized into 3 and 4 groups according to the tertile and quartile RTL values of controls, significant relationships were still observed between shorter RTL and increased CRC risk (OR per tertile = 1.13, 95%CI: 1.00-1.28, P(trend) = 0.045; OR per quartile = 1.12, 95%CI: 1.03-1.23, P(trend) = 0.012). In stratified analyses, significant association between shorter RTL and increased CRC risk was found in females, individuals younger than 60 years old, never smokers and never drinkers.
conclusionsThis study suggested that short telomere length in PBLs was significantly associated with an increased risk of CRC in Chinese Han population. Further validation in large prospective studies and investigation of the biologic mechanisms are warranted.
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