ArticlePloS one2014
Abnormal intrinsic brain activity patterns in patients with subcortical ischemic vascular dementia.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Functional brain changes in vascular cognitive impairment: a whole brain ALE meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- An ALE Meta-Analysis of Specific Functional MRI Studies on Subcortical Vascular Cognitive Impairment.Frontiers in neurology · 2021Pooled it
- Multimodal voxel-wise of structural and functional brain alterations across the cerebral small vessel disease spectrum.Neuroradiology · 2026Article
- Alterations in functional connectivity of the anterior cingulate cortex associated with different levels of tau and amyloid-Frontiers in neuroscience · 2026Article
- Concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease.Neuroradiology · 2025Article
- Resting-State fMRI Reveals the Neural Correlates of Acupuncture in the Treatment of Vascular Cognitive Impairment.Clinical interventions in aging · 2025Review
- Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia.Frontiers in aging neuroscience · 2025Review
- Cognitive impairment mediates the white matter injury load and gait disorders in subcortical ischemic vascular disease.Brain imaging and behavior · 2024Article
- Spatiotemporal consistency analysis of cerebral small vessel disease: an rs-fMRI study.Frontiers in neuroscience · 2024Article
- Altered static and dynamic indices of intrinsic brain activity in patients with subcortical ischemic vascular disease: a resting-state functional magnetic resonance imaging analysis.Neuroradiology · 2023Article
- Multimodality neuroimaging in vascular mild cognitive impairment: A narrative review of current evidence.Frontiers in aging neuroscience · 2023Review
- Altered intrinsic brain activity in patients with CSF1R-related leukoencephalopathy.Brain imaging and behavior · 2022Article
- Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment.Brain sciences · 2021Article
- White Matter Structural Network Analysis to Differentiate Alzheimer's Disease and Subcortical Ischemic Vascular Dementia.Frontiers in aging neuroscience · 2021Article
- Altered Dynamic Functional Connectivity in Subcortical Ischemic Vascular Disease With Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Large-scale network dysfunction in vascular cognitive disorder supports connectional diaschisis in advanced arteriosclerosis.European journal of neurology · 2020Article
- The Application of rs-fMRI in Vascular Cognitive Impairment.Frontiers in neurology · 2020Review
- Alterations in power spectral density in motor- and pain-related networks on neuropathic pain after spinal cord injury.NeuroImage. Clinical · 2020Article
- Observational
- Low-Frequency Fluctuations Amplitude Signals Exhibit Abnormalities of Intrinsic Brain Activities and Reflect Cognitive Impairment in Leukoaraiosis Patients.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the amplitude of low-frequency fluctuations (ALFF) alteration of whole brain in patients with subcortical ischemic vascular dementia (SIVD). MATERIALS AND
methodsThirty patients with SIVD and 35 control subjects were included in this study. All of them underwent structural MRI and rs-fMRI scan. The structural data were processed using the voxel-based morphometry 8 toolbox (VBM8). The rs-fMRI data were processed using Statistical Parametric Mapping (SPM8) and Data Processing Assistant for Resting-State fMRI (DPARSF) software. Within-group analysis was performed with a one-sample Student's t-test to identify brain regions with ALFF value larger than the mean. Intergroup analysis was performed with a two-sample Student's t-test to identify ALFF differences of whole brain between SIVD and control subjects. Partial correlations between ALFF values and Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) scores were analyzed in the SIVD group across the parameters of age, gender, years of education, and GM volume.
resultsWithin-group analysis showed that the bilateral anterior cingulate cortex (ACC), posterior cingulate cortex, medial prefrontal cortex (MPFC), inferior parietal lobe (IPL), occipital lobe, and adjacent precuneus had significantly higher standardized ALFF values than the global mean ALFF value in both groups. Compared to the controls, patients with SIVD presented lower ALFF values in the bilateral precuneus and higher ALFF values in the bilateral ACC, left insula and hippocampus. Including GM volume as an extra covariate, the ALFF inter-group difference exhibited highly similar spatial patterns to those without GM volume correcting. Close negative correlations were found between the ALFF values of left insula and the MoCA and MMSE scores of SIVD patients.
conclusionSIVD is associated with a unique spontaneous aberrant activity of rs-fMRI signals, and measurement of ALFF in the precuneus, ACC, insula, and hippocampus may aid in the detection of SIVD.
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