Trial reportPloS one2014
Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Respiratory system responses to a maximal apnoea.Experimental physiology · 2025Review
- Wearable Wireless Functional Near-Infrared Spectroscopy System for Cognitive Activity Monitoring.Biosensors · 2025Article
- Trends in competitive freediving accidents.Diving and hyperbaric medicine · 2024Article
- Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Hold your breath: peripheral and cerebral oxygenation during dry static apnea.European journal of applied physiology · 2020Article
- Impaired dynamic cerebral autoregulation in trained breath-hold divers.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Sudden Unexpected Death and the Mammalian Dive Response: Catastrophic Failure of a Complex Tightly Coupled System.Frontiers in physiology · 2019Article
- Cerebrovascular Reactivity during Prolonged Breath-Hold in Experienced Freedivers.AJNR. American journal of neuroradiology · 2018Article
- Cardiovascular magnetic resonance assessment of acute cardiovascular effects of voluntary apnoea in elite divers.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018Article
- Ictal Mammalian Dive Response: A Likely Cause of Sudden Unexpected Death in Epilepsy.Frontiers in neurology · 2018Article
- The association of kidney function with repetitive breath-hold diving activities of female divers from Korea, Haenyeo.BMC nephrology · 2017Article
- Regulation of brain blood flow and oxygen delivery in elite breath-hold divers.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo examine whether dynamic cerebral autoregulation is acutely impaired during maximal voluntary apnoea in trained divers.
methodsMean arterial pressure (MAP), cerebral blood flow-velocity (CBFV) and end-tidal partial pressures of O2 and CO2 (PETO2 and PETCO2) were measured in eleven trained, male apnoea divers (28 ± 2 yr; 182 ± 2 cm, 76 ± 7 kg) during maximal "dry" breath holding. Dynamic cerebral autoregulation was assessed by determining the strength of phase synchronisation between MAP and CBFV during maximal apnoea.
resultsThe strength of phase synchronisation between MAP and CBFV increased from rest until the end of maximal voluntary apnoea (P<0.05), suggesting that dynamic cerebral autoregulation had weakened by the apnoea breakpoint. The magnitude of impairment in dynamic cerebral autoregulation was strongly, and positively related to the rise in PETCO2 observed during maximal breath holding (R (2) = 0.67, P<0.05). Interestingly, the impairment in dynamic cerebral autoregulation was not related to the fall in PETO2 induced by apnoea (R (2) = 0.01, P = 0.75).
conclusionsThis study is the first to report that dynamic cerebral autoregulation is acutely impaired in trained divers performing maximal voluntary apnoea. Furthermore, our data suggest that the impaired autoregulatory response is related to the change in PETCO2, but not PETO2, during maximal apnoea in trained divers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.