ArticlePloS one2014
Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Association between telomere length and the risk of colorectal cancer: a meta-analysis of observational studies.BMC cancer · 2017Pooled it
- Short telomeres are associated with inferior outcome, genomic complexity, and clonal evolution in chronic lymphocytic leukemia.Leukemia · 2019Trial
- Characterization of blood-derived exosomal hTERT mRNA as a biomarker for colon cancer and Lynch syndrome.Frontiers in oncology · 2022Article
- Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel.British journal of cancer · 2018Article
- Hereditary Nonpolyposis Colorectal Cancer and Cancer Syndromes: Recent Basic and Clinical Discoveries.Journal of oncology · 2018Review
- Meta-analysis of associations between telomere length and colorectal cancer survival from observational studies.Oncotarget · 2017Article
- Familial Colorectal Cancer Type X.Current genomics · 2017Review
- Association of telomere length in peripheral leukocytes with chronic hepatitis B and hepatocellular carcinoma.Medicine · 2016Article
- Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps.Clinical and translational gastroenterology · 2016Article
- Telomere length in peripheral leukocytes is associated with immune cell tumor infiltration and prognosis in colorectal cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Toward a molecular classification of colorectal cancer: the role of telomere length.Frontiers in oncology · 2014Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found that cancer-affected MMR gene mutation carriers had shorter telomeres and more pronounced shortening of telomere length with age than controls and unaffected MMR gene mutation carriers. Here we evaluate blood telomere length in MMR-proficient hereditary non-polyposis CRC, i.e. familial CRC type X (fCRC-X). A total of 57 cancer-affected and 57 cancer-free individuals from 34 Amsterdam-positive fCRC-X families were analyzed and compared to the data previously published on 144 cancer-affected and 100 cancer-free MMR gene mutation carriers, and 234 controls. Relative telomere length was measured using a monochrome multiplex quantitative PCR method, following strict measures to avoid sources of bias and adjusting by age. Despite the retrospective nature of our study, the results show that longer telomeres associate with cancer risk in fCRC-X, thus identifying different patterns of telomere length according to the status of the MMR system.
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