Trial reportPloS one2014
Distribution and development of peripheral glial cells in the human fetal cochlea.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Engineering of functional auditory neurons from human induced pluripotent stem cells.Military Medical Research · 2026Article
- Review
- Investigating cochlear cellular dynamics in neurofibromatosis type 2-associated schwannomatosis: a histopathological study.Frontiers in neurology · 2025Article
- Schwann cells in the inner ear: development, disease, and regeneration.Frontiers in cellular neuroscience · 2025Review
- SOX2, JAGGED1, β-Catenin, and Vitamin D Receptor Expression Patterns during Early Development and Innervation of the Human Inner Ear.International journal of molecular sciences · 2024Article
- Article
- Protection from cisplatin-induced hearing loss with lentiviral vector-mediated ectopic expression of the anti-apoptotic protein BCL-XL.Molecular therapy. Nucleic acids · 2024Article
- Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro.Development (Cambridge, England) · 2023Article
- Developmental expression of high-mobility group box 1 (HMGB1) in the mouse cochlea.European journal of histochemistry : EJH · 2023Article
- Generation of human otic neuronal organoids using pluripotent stem cells.Cell proliferation · 2023Article
- Transcriptional response to mild therapeutic hypothermia in noise-induced cochlear injury.Frontiers in neuroscience · 2023Article
- Cellular distribution of the Fragile X mental retardation protein in the inner ear: a developmental and comparative study in the mouse, rat, gerbil, and chicken.The Journal of comparative neurology · 2023Article
- Complement factor B is essential for the proper function of the peripheral auditory system.Frontiers in neurology · 2023Article
- Early development of the cochlea of the common marmoset, a non-human primate model.Neural development · 2022Article
- Axon-glia interactions in the ascending auditory system.Developmental neurobiology · 2021Review
- Migration and fate of vestibular melanocytes during the development of the human inner ear.Developmental neurobiology · 2020Article
- Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Age-dependent alterations of Kir4.1 expression in neural crest-derived cells of the mouse and human cochlea.Neurobiology of aging · 2019Article
- Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors.Nature communications · 2018Article
- Transient auditory nerve demyelination as a new mechanism for hidden hearing loss.Nature communications · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adult human cochlea contains various types of peripheral glial cells that envelop or myelinate the three different domains of the spiral ganglion neurons: the central processes in the cochlear nerve, the cell bodies in the spiral ganglia, and the peripheral processes in the osseous spiral lamina. Little is known about the distribution, lineage separation and maturation of these peripheral glial cells in the human fetal cochlea. In the current study, we observed peripheral glial cells expressing SOX10, SOX9 and S100B as early as 9 weeks of gestation (W9) in all three neuronal domains. We propose that these cells are the common precursor to both mature Schwann cells and satellite glial cells. Additionally, the peripheral glial cells located along the peripheral processes expressed NGFR, indicating a phenotype distinct from the peripheral glial cells located along the central processes. From W12, the spiral ganglion was gradually populated by satellite glial cells in a spatiotemporal gradient. In the cochlear nerve, radial sorting was accomplished by W22 and myelination started prior to myelination of the peripheral processes. The developmental dynamics of the peripheral glial cells in the human fetal cochlea is in support of a neural crest origin. Our study provides the first overview of the distribution and maturation of peripheral glial cells in the human fetal cochlea from W9 to W22.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.