ArticlePloS one2014
Genome wide analysis indicates genes for basement membrane and cartilage matrix proteins as candidates for hip dysplasia in Labrador Retrievers.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review.Frontiers in veterinary science · 2020Pooled it
- Prevalence of hip and elbow dysplasia in young adult dogs in Sweden.The Veterinary record · 2026Article
- The markers of the predictive DNA test for canine hip dysplasia may have a stronger relationship with elbow dysplasia.Heliyon · 2024Article
- Genome wide association study in Swedish Labrador retrievers identifies genetic loci associated with hip dysplasia and body weight.Scientific reports · 2024Article
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- B-mode ultrasonography and ARFI elastography of articular and peri-articular structures of the hip joint in non-dysplastic and dysplastic dogs as confirmed by radiographic examination.BMC veterinary research · 2023Article
- Identification of basement membrane-related biomarkers associated with the diagnosis of osteoarthritis based on machine learning.BMC medical genomics · 2023Article
- Whole exome sequencing of 28 families of Danish descent reveals novel candidate genes and pathways in developmental dysplasia of the hip.Molecular genetics and genomics : MGG · 2023Article
- Across-breed genetic investigation of canine hip dysplasia, elbow dysplasia, and anterior cruciate ligament rupture using whole-genome sequencing.Frontiers in genetics · 2022Article
- Article
- Genomic Prediction of Two Complex Orthopedic Traits Across Multiple Pure and Mixed Breed Dogs.Frontiers in genetics · 2021Article
- COL3A1, COL6A3, and SERPINH1 Are Related to Glucocorticoid-Induced Osteoporosis Occurrence According to Integrated Bioinformatics Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Genome-wide association study to identify canine hip dysplasia loci in dogs.Journal of animal science and technology · 2020Article
- The association of genetic polymorphisms of bone formation genes with canine hip dysplasia.Iranian journal of veterinary research · 2020Article
- Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci.BMC genomics · 2019Article
- Novel protective and risk loci in hip dysplasia in German Shepherds.PLoS genetics · 2019Article
- Long-term genetic selection reduced prevalence of hip and elbow dysplasia in 60 dog breeds.PloS one · 2017Article
- Article
- Insights in the etiopathology of galactosyltransferase II (GalT-II) deficiency from transcriptome-wide expression profiling of skin fibroblasts of two sisters with compound heterozygosity for two novelMolecular genetics and metabolism reports · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hip dysplasia, an abnormal laxity of the hip joint, is seen in humans as well as dogs and is one of the most common skeletal disorders in dogs. Canine hip dysplasia is considered multifactorial and polygenic, and a variety of chromosomal regions have been associated with the disorder. We performed a genome-wide association study in Dutch Labrador Retrievers, comparing data of nearly 18,000 single nucleotide polymorphisms (SNPs) in 48 cases and 30 controls using two different statistical methods. An individual SNP analysis based on comparison of allele frequencies with a χ(2) statistic was used, as well as a simultaneous SNP analysis based on Bayesian variable selection. Significant association with canine hip dysplasia was observed on chromosome 8, as well as suggestive association on chromosomes 1, 5, 15, 20, 25 and 32. Next-generation DNA sequencing of the exons of genes of seven regions identified multiple associated alleles on chromosome 1, 5, 8, 20, 25 and 32 (p<0.001). Candidate genes located in the associated regions on chromosomes 1, 8 and 25 included LAMA2, LRR1 and COL6A3, respectively. The associated region on CFA20 contained candidate genes GDF15, COMP and CILP2. In conclusion, our study identified candidate genes that might affect susceptibility to canine hip dysplasia. These genes are involved in hypertrophic differentiation of chondrocytes and extracellular matrix integrity of basement membrane and cartilage. The functions of the genes are in agreement with the notion that disruptions in endochondral bone formation in combination with soft tissue defects are involved in the etiology of hip dysplasia.
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