ArticlePloS one2014
Association mapping provides insights into the origin and the fine structure of the sorghum aluminum tolerance locus, AltSB.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Systematic Investigation of Aluminum Stress-Related Genes and Their Critical Roles in Plants.International journal of molecular sciences · 2024Review
- How a Long-Term Cover Crop Cultivation Impacts Soil Phosphorus Availability in a No-Tillage System?Plants (Basel, Switzerland) · 2024Article
- Integrating genomics and genome editing for orphan crop improvement: a bridge between orphan crops and modern agriculture system.GM crops & food · 2023Review
- Association mapping and genomic selection for sorghum adaptation to tropical soils of Brazil in a sorghum multiparental random mating population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Identification and Expression of the Multidrug and Toxic Compound Extrusion (MATE) Gene Family inPlants (Basel, Switzerland) · 2020Article
- Fine mapping and gene cloning in the post-NGS era: advances and prospects.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Review
- Repeat variants for the SbMATE transporter protect sorghum roots from aluminum toxicity by transcriptional interplay inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Exploiting sorghum genetic diversity for enhanced aluminum tolerance: Allele mining based on the AltScientific reports · 2018Article
- Molecular markers associated with aluminium tolerance inHereditas · 2018Article
- Emerging Pleiotropic Mechanisms Underlying Aluminum Resistance and Phosphorus Acquisition on Acidic Soils.Frontiers in plant science · 2018Review
- Association mapping of drought tolerance-related traits in barley to complement a traditional biparental QTL mapping study.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Quantitative trait loci from identification to exploitation for crop improvement.Plant cell reports · 2017Review
- The similar and different evolutionary trends of MATE family occurred between rice and Arabidopsis thaliana.BMC plant biology · 2016Article
- Glutathione S-transferases and UDP-glycosyltransferases Are Involved in Response to Aluminum Stress in Flax.Frontiers in plant science · 2016Article
- Association Mapping for Aluminum Tolerance in a Core Collection of Rice Landraces.Frontiers in plant science · 2016Article
- Back to Acid Soil Fields: The Citrate Transporter SbMATE Is a Major Asset for Sustainable Grain Yield for Sorghum Cultivated on Acid Soils.G3 (Bethesda, Md.) · 2015Article
- GHRH, PRP-PACAP and GHRHR Target Sequencing via an Ion Torrent Personal Genome Machine Reveals an Association with Growth in Orange-Spotted Grouper (Epinephelus coioides).International journal of molecular sciences · 2015Article
- Duplicate and conquer: multiple homologs of PHOSPHORUS-STARVATION TOLERANCE1 enhance phosphorus acquisition and sorghum performance on low-phosphorus soils.Plant physiology · 2014Article
- Two in one sweep: aluminum tolerance and grain yield in P-limited soils are associated to the same genomic region in West African sorghum.BMC plant biology · 2014Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root damage caused by aluminum (Al) toxicity is a major cause of grain yield reduction on acid soils, which are prevalent in tropical and subtropical regions of the world where food security is most tenuous. In sorghum, Al tolerance is conferred by SbMATE, an Al-activated root citrate efflux transporter that underlies the major Al tolerance locus, AltSB, on sorghum chromosome 3. We used association mapping to gain insights into the origin and evolution of Al tolerance in sorghum and to detect functional variants amenable to allele mining applications. Linkage disequilibrium across the AltSB locus decreased much faster than in previous reports in sorghum, and reached basal levels at approximately 1000 bp. Accordingly, intra-locus recombination events were found to be extensive. SNPs and indels highly associated with Al tolerance showed a narrow frequency range, between 0.06 and 0.1, suggesting a rather recent origin of Al tolerance mutations within AltSB. A haplotype network analysis suggested a single geographic and racial origin of causative mutations in primordial guinea domesticates in West Africa. Al tolerance assessment in accessions harboring recombinant haplotypes suggests that causative polymorphisms are localized to a ∼6 kb region including intronic polymorphisms and a transposon (MITE) insertion, whose size variation has been shown to be positively correlated with Al tolerance. The SNP with the strongest association signal, located in the second SbMATE intron, recovers 9 of the 14 highly Al tolerant accessions and 80% of all the Al tolerant and intermediately tolerant accessions in the association panel. Our results also demonstrate the pivotal importance of knowledge on the origin and evolution of Al tolerance mutations in molecular breeding applications. Allele mining strategies based on associated loci are expected to lead to the efficient identification, in diverse sorghum germplasm, of Al tolerant accessions able maintain grain yields under Al toxicity.
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