Evidence map›Paper›PMID 24498072›Full record

ArticlePloS one2014

Vitamin D and caudal primary motor cortex: a magnetic resonance spectroscopy study.

Cedric Annweiler, Olivier Beauchet, Robert Bartha, Vladimir Hachinski, Manuel Montero-Odasso, WALK Team (Working group Angers-London for Knowledge)

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02808676 (SYNchronizing Exercises, Remedies in GaIt and Cognition), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02808676 naterminatednot on this mapstarted 2016, after this paper: background citation

SYNchronizing Exercises, Remedies in GaIt and Cognition (SYNERGIC): A Randomized Controlled Double Blind Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2016 to 2020Enrolled175ConditionsMild Cognitive ImpairmentArmsVitamin D3, Exercises (E), Cognitive Training (CT), placebo D3, control cognitive training
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Cedric AnnweilerGait and Brain Lab, Lawson Health Research Institute, Parkwood Hospital, The University of Western Ontario, London, Ontario, Canada ; Division of Geriatric Medicine, University Hospital; Memory Clinic; UPRES EA 4638, University of Angers, Angers, France ; Robarts Research Institute, the University of Western Ontario, London, Ontario, Canada.
Olivier BeauchetDivision of Geriatric Medicine, University Hospital; Memory Clinic; UPRES EA 4638, University of Angers, Angers, France.
Robert BarthaRobarts Research Institute, the University of Western Ontario, London, Ontario, Canada.
Vladimir HachinskiDepartment of Clinical Neurological Sciences, University Hospital, the University of Western Ontario, London, Ontario, Canada.
Manuel Montero-OdassoGait and Brain Lab, Lawson Health Research Institute, Parkwood Hospital, The University of Western Ontario, London, Ontario, Canada.
WALK Team (Working group Angers-London for Knowledge)
Western University · CAParkwood Institute · CAUniversité d'Angers · FR

Funding

Canadian Institutes of Health Research 211220
6 · The paper itself

Abstract

backgroundVitamin D is involved in brain physiology and lower-extremity function. We investigated spectroscopy in a cohort of older adults to explore the hypothesis that lower vitamin D status was associated with impaired neuronal function in caudal primary motor cortex (cPMC) measured by proton magnetic resonance spectroscopic imaging.

methodsTwenty Caucasian community-dwellers (mean±standard deviation, 74.6±6.2 years; 35.0% female) from the 'Gait and Brain Study' were included in this analysis. Ratio of N-acetyl-aspartate to creatine (NAA/Cr), a marker of neuronal function, was calculated in cPMC. Participants were categorized according to mean NAA/Cr. Lower vitamin D status was defined as serum 25-hydroxyvitamin D (25OHD) concentration <75 nmol/L. Age, gender, number of comorbidities, vascular risk, cognition, gait performance, vitamin D supplements, undernourishment, cPMC thickness, white matter hyperintensities grade, serum parathyroid hormone concentration, and season of evaluation were used as potential confounders.

resultsCompared to participants with high NAA/Cr (n = 11), those with low NAA/Cr (i.e., reduced neuronal function) had lower serum 25OHD concentration (P = 0.044) and more frequently lower vitamin D status (P = 0.038). Lower vitamin D status was cross-sectionally associated with a decrease in NAA/Cr after adjustment for clinical characteristics (β = -0.41, P = 0.047), neuroimaging measures (β = -0.47, P = 0.032) and serum measures (β = -0.45, P = 0.046).

conclusionsLower vitamin D status was associated with reduced neuronal function in cPMC. These novel findings need to be replicated in larger and preferably longitudinal cohorts. They contribute to explain the pathophysiology of gait disorders in older adults with lower vitamin D status, and provide a scientific base for vitamin D replacement trials.

Indexed as

AgedAged, 80 and overAspartic AcidCognitionCohort StudiesCreatineFemaleGaitHumansLinear ModelsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMotor CortexMultivariate AnalysisNeurons25-hydroxyvitamin DAspartic AcidCreatineN-acetylaspartateParathyroid HormoneVitamin D

Identifiers

PMID24498072
PMCPMC3909095
OpenAlexW2060852233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.