ArticleKorean circulation journal2014
Prognostic Implication of QRS Variability during Hospitalization in Patients with Acute Decompensated Heart Failure.
Article in Korean circulation journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors at 2 institutions in 1 country.
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Abstract
BACKGROUND AND
objectivesHeart failure (HF) patients display more varied QRS duration. We investigated whether QRS variability during hospitalization for acute decompensated HF is associated with poor clinical outcomes after discharge. SUBJECTS AND
methodsOne hundred seventy three patients (64% males; age 60±13 years) admitted for acute decompensated HF with severe left ventricular (LV) dysfunction (LV ejection fraction ≤35%) were consecutively enrolled. QRS variability was calculated by the difference between maximum and minimum QRS duration acquired during hospitalization. The prognostic implications on composite endpoints of death or urgent heart transplantation were analyzed.
resultsForty-two patients (24.3%) died and three patients (1.7%) underwent urgent heart transplantation during the follow-up of 51±18 months. Patients who reached composite endpoints (n=45) showed greater QRS variability than those who did not (n=128) (20±23 ms vs. 14±14 ms, p=0.046). Patients who had high QRS variability (more than 22 ms; n=36) tended to have a higher event rate than those with QRS variability <22 ms {39% vs. 23%, hazard ratio (HR), 1.88; 95% confidence interval (CI) 1.001-3.539, p=0.05}. Adjusting with other variables, high QRS variability was an independent predictor for composite outcome (HR 1.94; 95% CI 1.023-3.683, p=0.042).
conclusionQRS variability measured during hospitalization for acute decompensated HF has a prognostic impact in HF patients with severe LV dysfunction.
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