ArticleIndian journal of human genetics2013
Chromosomal abnormalities in couples with repeated fetal loss: An Indian retrospective study.
Article in Indian journal of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases.Chromosoma · 2022Pooled it
- Article
- Complex chromosomal rearrangements in female carriers experiencing recurrent pregnancy loss or poor obstetric history and literature review.Journal of assisted reproduction and genetics · 2025Review
- Evaluation of chromosomal abnormalities in the postnatal cohort: A single-center study on 14,242 patients.Journal of clinical laboratory analysis · 2024Article
- Prevalence of Chromosomal Abnormalities in Iranian Patients with Infertility.Archives of Iranian medicine · 2023Article
- High incidences of chromosomal aberrations and Y chromosome micro-deletions as prominent causes for recurrent pregnancy losses in highly ethnic and consanguineous population.Archives of gynecology and obstetrics · 2022Article
- Cytogenetic analysis of 2959 couples with spontaneous abortion and detailed analysis of rare karyotypes.Journal of genetics · 2022Article
- High and Low Haemoglobin Levels in Early Pregnancy Are Associated to a Higher Risk of Miscarriage: A Population-Based Cohort Study.Nutrients · 2021Article
- Parental balanced chromosomal rearrangement leading to major genomic imbalance and an autosomal trisomy resulting in consecutive pregnancy loss: a case report.Journal of genetics · 2021Article
- Combination of QF-PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage.Molecular genetics & genomic medicine · 2019Article
- Effects of chromosome 9 inversion on IVF/ICSI: A 7-year retrospective cohort study.Molecular genetics & genomic medicine · 2019Article
- The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9).Reproductive medicine and biology · 2019Article
- Subtelomeric Rearrangements in Patients with Recurrent Miscarriage.International journal of fertility & sterility · 2018Article
- Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2018Review
- Balanced Autosomal Translocations in Two Women Reporting Recurrent Miscarriage.Journal of clinical and diagnostic research : JCDR · 2016Article
- Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India.Journal of genetics · 2016Article
- Somatic/gonadal mosaicism for structural autosomal rearrangements: female predominance among carriers of gonadal mosaicism for unbalanced rearrangements.Molecular cytogenetics · 2016Review
- Cytogenetic Screening in Couples with Recurrent Pregnancy Loss: A Single-Center Study and Review of Literature.Journal of human reproductive sciencesArticle
- A Case-Control Study Identifying the Frequency and Spectrum of Chromosomal Anomalies and Variants in a Cohort of 1000 Couples with a Known History of Recurrent Pregnancy Loss in the Eastern Region of India.Journal of human reproductive sciencesArticle
- A Novel Balanced Chromosomal Translocation in an Azoospermic Male: A Case Report.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecurrent pregnancy loss is a common occurrence and a matter of concern for couples planning the pregnancy. Chromosomal abnormalities, mainly balanced rearrangements, are common in couples with repeated miscarriages. PURPOSE: The purpose of this study is to evaluate the contribution of chromosomal anomalies causing repeated spontaneous miscarriages and provide detailed characterization of a few structurally altered chromosomes. MATERIALS AND
methodsA retrospective cytogenetic study was carried out on 4859 individuals having a history of recurrent miscarriages. The cases were analyzed using G-banding and fluorescence in situ hybridization wherever necessary.
resultsChromosomal rearrangements were found in 170 individuals (3.5%). Translocations were seen in 72 (42.35%) cases. Of these, reciprocal translocations constituted 42 (24.70%) cases while Robertsonian translocations were detected in 30 (17.64%) cases. 7 (4.11%) cases were mosaic, 8 (4.70%) had small supernumerary marker chromosomes and 1 (0.6%) had an interstitial microdeletion. Nearly, 78 (1.61%) cases with heteromorphic variants were seen of which inversion of Y chromosome (57.70%) and chromosome 9 pericentromeric variants (32.05%) were predominantly involved.
conclusionsChromosomal analysis is an important etiological investigation in couples with repeated miscarriages. Characterization of variants/marker chromosome enable calculation of a more precise recurrent risk in a subsequent pregnancy thereby facilitating genetic counseling and deciding further reproductive options.
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