ArticleSleep2014
Decreased connectivity between the thalamus and the neocortex during human nonrapid eye movement sleep.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 92 citations in OpenAlex.
- Effective connectivity changes in LSD-induced altered states of consciousness in humans.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
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- Differential engagement of thalamic nuclei orchestrates consciousness states across anesthesia, sleep, and disorders of consciousness.Communications biology · 2025Article
- Sleep neuroimaging: Review and future directions.Journal of sleep research · 2025Review
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- Nucleus Reuniens-Elicited Delta Oscillations Disable the Prefrontal Cortex in Schizophrenia.Cells · 2025Review
- Sleep State Influences Early Sound Encoding at Cortical But Not Subcortical Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development.Developmental cognitive neuroscience · 2025Review
- Arousal threshold reveals novel neural markers of sleep depth independently from the conventional sleep stages.bioRxiv : the preprint server for biology · 2025Article
- Prenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing.Autism research : official journal of the International Society for Autism Research · 2024Article
- Article
- Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Facilitation of Behavioral and Cortical Emergence from Isoflurane Anesthesia by GABAergic Neurons in Basal Forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Associations between resting state brain activity and AFrontiers in neuroscience · 2023Article
- Genetic and neural mechanisms of sleep disorders in children with autism spectrum disorder: a review.Frontiers in psychiatry · 2023Review
- Sleep Problems in Preschoolers With Autism Spectrum Disorder Are Associated With Sensory Sensitivities and Thalamocortical Overconnectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state.Nature communications · 2022Article
- A pilot study to understand the relationship between cortical arousals and leg movements during sleep.Scientific reports · 2022Article
- Selective blockade of rat brain T-type calcium channels provides insights on neurophysiological basis of arousal dependent resting state functional magnetic resonance imaging signals.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
STUDY
objectivesTo determine whether thalamocortical signaling between the thalamus and the neocortex decreases from wakefulness to nonrapid eye movement (NREM) sleep.
designElectroencephalography and functional magnetic resonance imaging data were collected simultaneously at 02:30 after 44 h of sleep deprivation.
settingClinical research hospital.
participantsThere were six volunteers (mean age 24.2 y, one male) who yielded sufficient amounts of usable, artifact-free data. All were healthy, right-handed native English speakers who consumed less than 710 mL of caffeinated beverages per day. Psychiatric, neurological, circadian, and sleep disorders were ruled out by reviewing each patient's clinical history. A standard clinical nocturnal polysomnogram was negative for sleep disorders.
interventionsN/A. MEASUREMENTS AND
resultsA functional connectivity analysis was performed using the centromedian nucleus as the seed region. We determined the statistical significance of the difference between correlations obtained during wakefulness and during slow wave sleep. Neocortical regions displaying decreased thalamic connectivity were all heteromodal regions (e.g., medial frontal gyrus and posterior cingulate/precuneus), whereas there was a complete absence of neocortical regions displaying increased thalamic connectivity. Although more clusters of significant decreases were observed in stage 2 sleep, these results were similar to the results for slow wave sleep.
conclusionsResults of this study provide evidence of a functional deafferentation of the neocortex during nonrapid eye movement (NREM) sleep in humans. This deafferentation likely accounts for increased sensory awareness thresholds during NREM sleep. Decreased thalamocortical connectivity in regions such as the posterior cingulate/precuneus also are observed in coma and general anesthesia, suggesting that changes in thalamocortical connectivity may act as a universal "control switch" for changes in consciousness that are observed in coma, general anesthesia, and natural sleep.
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