ArticleSleep2014
Restless legs syndrome: an early clinical feature of Parkinson disease in men.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.Sleep medicine reviews · 2017Pooled it
- Associations Between Sleep and Non-Motor Symptoms in RBD-Screened Suspected Prodromal Parkinson's Disease with Hyposmia or Orthostatic Hypotension.Journal of clinical medicine · 2026Article
- Pathophysiology and pharmacological management for sleep problems in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review.Journal of clinical medicine · 2026Review
- Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Persistent Tremor in Bipolar Disorder: A Case Report of Idiopathic Parkinson's Disease Superimposed on Lithium and Antipsychotic Effects.Case reports in psychiatry · 2026Article
- Risk of Parkinson Disease Among Patients With Restless Leg Syndrome.JAMA network open · 2025Article
- Concomitant Pathologies and Their Impact on Parkinson Disease: A Narrative Overview of Current Evidence.International journal of molecular sciences · 2025Review
- Sleep Disturbance in Parkinson's Disease: Consequences for the Brain and Disease Progression - A Narrative Review.Nature and science of sleep · 2025Review
- A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson's disease.Nature communications · 2023Article
- A genome-wide association study coupled with machine learning approaches to identify influential demographic and genomic factors underlying Parkinson's disease.Frontiers in genetics · 2023Article
- Longitudinal Studies of Sleep Disturbances in Parkinson's Disease.Current neurology and neuroscience reports · 2022Review
- Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease.Journal of Parkinson's disease · 2022Article
- Restless Chest Syndrome: A Rare Variant of Restless Legs Syndrome.European journal of case reports in internal medicine · 2022Article
- Association of BST1 polymorphism with idiopathic restless legs syndrome in Chinese population.Sleep & breathing = Schlaf & Atmung · 2021Article
- Does Restless Legs Syndrome Have a Different Pathomechanism in Premotor and Motor Parkinson's Disease?Journal of movement disorders · 2021Article
- Hippocampal and Reticulo-Thalamic Parvalbumin Interneurons and Synaptic Re-Organization during Sleep Disorders in the Rat Models of Parkinson's Disease Neuropathology.International journal of molecular sciences · 2021Article
- Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Association of Sleepwalking and REM Sleep Behavior Disorder With Parkinson Disease in Men.JAMA network open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
STUDY
objectiveThe association between restless legs syndrome (RLS) and Parkinson disease has been extensively studied, but the temporal relationship between the two remains unclear. We thus conduct the first prospective study to examine the risk of developing Parkinson disease in RLS.
designProspective study from 2002-2010.
settingUnited States.
participantsThere were 22,999 US male health professionals age 40-75 y enrolled in the Health Professionals Follow-up Study without Parkinson disease, arthritis, or diabetes mellitus at baseline. MEASUREMENT AND
resultsRLS was assessed in 2002 using a set of standardized questions recommended by the International RLS Study Group. Incident Parkinson disease was identified by biennial questionnaires and then confirmed by review of participants' medical records by a movement disorder specialist. We documented 200 incident Parkinson disease cases during 8 y of follow-up. Compared to men without RLS, men with RLS symptoms who had symptoms greater than 15 times/mo had higher risk of Parkinson disease development (adjusted relative risk = 1.47; 95% confidence interval: 0.59, 3.65; P = 0.41). This was statistically significant only for cases diagnosed within 4 y of follow-up (adjusted relative risk = 2.77; 95% confidence interval: 1.08, 7.11; P = 0.03).
conclusionSevere restless legs syndrome may be an early feature of Parkinson disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.