ArticleSleep2014
Sleep duration and depressive symptoms: a gene-environment interaction.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Relationship between night-sleep duration and risk for depression among middle-aged and older people: A dose-response meta-analysis.Frontiers in physiology · 2023Pooled it
- Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium.Sleep · 2016Pooled it
- Effect of cognitive behavioral therapy program on mental health status among medical student in Palestine during COVID pandemic.BMC psychiatry · 2022Trial
- Impact of earplugs and eye mask on sleep in critically ill patients: a prospective randomized study.Critical care (London, England) · 2017Trial
- [Associations of sleep duration with mental health and alcohol use among Korean adults: a secondary analysis of the Korea National Health and Nutrition Examination Survey (2018·2020)].Journal of Korean biological nursing science · 2025Article
- Association among objective and subjective sleep duration, depressive symptoms and all-cause mortality: the pathways study.BMC psychiatry · 2025Article
- Nonlinear associations of nighttime sleep and protective napping with depressive symptoms: a cross-sectional analysis from the China Family Panel Studies.Frontiers in psychiatry · 2025Article
- Changes in sleep patterns in people with a history of depression during the COVID-19 pandemic: a natural experiment.BMJ mental health · 2024Article
- The mediating role of sleep disturbance in the relationship between depression and cardiovascular disease.Frontiers in psychiatry · 2024Article
- Associations of sleep duration, daytime napping, and snoring with depression in rural China: a cross-sectional study.BMC public health · 2023Article
- Mediating Effect of Quality of Sleep Moderated by Meaning in Life on the Relationship between Hwabyung and Suicidal Ideation in Middle-Aged Korean Women.Behavioral sciences (Basel, Switzerland) · 2023Article
- Comparison of Sleep Disturbance, Physical Activity, and Health-Related Quality of Life According to Depressive Symptoms in Patients with Metabolic Syndrome: A Secondary Analysis from the Korea National Health and Nutrition Examination Survey Using a Propensity Score Matching Analysis.Healthcare (Basel, Switzerland) · 2023Article
- Interactive effects of sleep and physical activity on depression among rural university students in China.Frontiers in psychology · 2023Article
- Association of sleep behavior with depression: a cross-sectional study in northwestern China.Frontiers in psychiatry · 2023Article
- Association of sleep duration and quality with depression Among University Students and Faculty.Acta bio-medica : Atenei Parmensis · 2022Article
- Does sleep duration moderate genetic and environmental contributions to cognitive performance?Sleep · 2022Article
- Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms.Scientific reports · 2022Article
- The association between sleep and depressive symptoms in US adults: data from the NHANES (2007-2014).Epidemiology and psychiatric sciences · 2022Article
- The fall of vulnerability to sleep disturbances in evening chronotypes when working from home and its implications for depression.Scientific reports · 2022Article
- Exploring polygenic-environment and residual-environment interactions for depressive symptoms within the UK Biobank.Genetic epidemiology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveWe used quantitative genetic models to assess whether sleep duration modifies genetic and environmental influences on depressive symptoms.
methodParticipants were 1,788 adult twins from 894 same-sex twin pairs (192 male and 412 female monozygotic [MZ] pairs, and 81 male and 209 female dizygotic [DZ] pairs] from the University of Washington Twin Registry. Participants self-reported habitual sleep duration and depressive symptoms. Data were analyzed using quantitative genetic interaction models, which allowed the magnitude of additive genetic, shared environmental, and non-shared environmental influences on depressive symptoms to vary with sleep duration.
resultsWithin MZ twin pairs, the twin who reported longer sleep duration reported fewer depressive symptoms (ec = -0.17, SE = 0.06, P < 0.05). There was a significant gene × sleep duration interaction effect on depressive symptoms (a'c = 0.23, SE = 0.08, P < 0.05), with the interaction occurring on genetic influences that are common to both sleep duration and depressive symptoms. Among individuals with sleep duration within the normal range (7-8.9 h/night), the total heritability (h2) of depressive symptoms was approximately 27%. However, among individuals with sleep duration within the low (< 7 h/night) or high (≥ 9 h/night) range, increased genetic influence on depressive symptoms was observed, particularly at sleep duration extremes (5 h/night: h2 = 53%; 10 h/night: h2 = 49%).
conclusionGenetic contributions to depressive symptoms increase at both short and long sleep durations.
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