ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2014
Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Molecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.International journal of molecular sciences · 2026Review
- The importance of taste on swallowing function.Frontiers in nutrition · 2024Review
- Multi-Omics Unravels Metabolic Alterations in the Ileal Mucosa of Neonatal Piglets Receiving Total Parenteral Nutrition.Metabolites · 2023Article
- Adenosine 2A receptor contributes to the facilitation of post-infectious irritable bowel syndrome by γδ T cellsWorld journal of gastroenterology · 2023Article
- Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders.Nutrients · 2022Review
- Glutamate attenuates lipopolysaccharide induced intestinal barrier injury by regulating corticotropin-releasing factor pathway in weaned pigs.Animal bioscience · 2022Article
- Low-protein diets supplemented with glutamic acid or aspartic acid ameliorate intestinal damage in weaned piglets challenged with hydrogen peroxide.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Calcium regulation of stem cells.EMBO reports · 2020Review
- Effect of dietaryAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2020Article
- Fish oil-derived lipid emulsion induces RIP1-dependent and caspase 8-licensed necroptosis in IEC-6 cells through overproduction of reactive oxygen species.Lipids in health and disease · 2018Article
- Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract.World journal of gastroenterology · 2017Review
- Inducible and neuronal nitric oxide synthases exert contrasting effects during rat intestinal recovery following fasting.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Tight Junction Ultrastructure Alterations in a Mouse Model of Enteral Nutrient Deprivation.Digestive diseases and sciences · 2016Article
- Differential expression of pancreatic protein and chemosensing receptor mRNAs in NKCC1-null intestine.World journal of gastrointestinal pathophysiology · 2016Article
- Article
- Intestine, immunity, and parenteral nutrition in an era of preferred enteral feeding.Current opinion in clinical nutrition and metabolic care · 2015Review
- Modulation of intestinal L-glutamate transport by luminal leptin.Journal of physiology and biochemistry · 2015Article
- Duodenal luminal nutrient sensing.Current opinion in pharmacology · 2014Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Small intestine luminal nutrient sensing may be crucial for modulating physiological functions. However, its mechanism of action is incompletely understood. We used a model of enteral nutrient deprivation, or total parenteral nutrition (TPN), resulting in intestinal mucosal atrophy and decreased epithelial barrier function (EBF). We examined how a single amino acid, glutamate (GLM), modulates intestinal epithelial cell (IEC) growth and EBF. Controls were chow-fed mice, T1 receptor-3 (T1R3)-knockout (KO) mice, and treatment with the metabotropic glutamate receptor (mGluR)-5 antagonist MTEP. TPN significantly changed the amount of T1Rs, GLM receptors, and transporters, and GLM prevented these changes. GLM significantly prevented TPN-associated intestinal atrophy (2.5-fold increase in IEC proliferation) and was dependent on up-regulation of the protein kinase pAkt, but independent of T1R3 and mGluR5 signaling. GLM led to a loss of EBF with TPN (60% increase in FITC-dextran permeability, 40% decline in transepithelial resistance); via T1R3, it protected EBF, whereas mGluR5 was associated with EBF loss. GLM led to a decline in circulating glucagon-like peptide 2 (GLP-2) during TPN. The decline was regulated by T1R3 and mGluR5, suggesting a novel negative regulator pathway for IEC proliferation not previously described. Loss of luminal nutrients with TPN administration may widely affect intestinal taste sensing. GLM has previously unrecognized actions on IEC growth and EBF. Restoring luminal sensing via GLM could be a strategy for patients on TPN.
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Registered trials
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