ReviewNeurosurgical review2014
Rates and predictors of seizure freedom in resective epilepsy surgery: an update.
Review in Neurosurgical review, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 6 syntheses or guidelines pooled it, 218 citations in OpenAlex.
- Focused ultrasound for treatment of epilepsy: a systematic review and meta-analysis of preclinical and clinical studies.Neurosurgical review · 2024Pooled it
- Long-term follow-up seizure outcomes after corpus callosotomy: A systematic review with meta-analysis.Brain and behavior · 2023Pooled it
- Multiple Subpial Transections for Medically Refractory Epilepsy: A Disaggregated Review of Patient-Level Data.Neurosurgery · 2018Pooled it
- Rates and Predictors of Seizure Freedom With Vagus Nerve Stimulation for Intractable Epilepsy.Neurosurgery · 2016Pooled it
- Clinical outcomes and quality of life following surgical treatment for refractory epilepsy: a systematic review and meta-analysis.Medicine · 2015Pooled it
- The Role of Hemosiderin Excision in Seizure Outcome in Cerebral Cavernous Malformation Surgery: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Directed graph neural networks with partial directed coherence for seizure prediction and epileptogenic network characterization.iScience · 2026Article
- Nucleus basalis functional connectivity aberrations in temporal lobe epilepsy and improvements after successful epilepsy surgery.Epilepsia · 2026Article
- Review
- The seizure embedding map: a spatio-temporal transformer for comparing patients by ictal intracranial EEG features at scale.Journal of neural engineering · 2026Article
- Review
- Article
- Pathway to Adaptive Neuromodulation: Modeling Epileptogenic Brain States Using SEEG.Epilepsy currents · 2026Article
- Locating the epileptogenic zone for drug-resistant epilepsy through neuroelectrophysiological brain network topology.Frontiers in neuroscience · 2026Article
- Collapse of interictal suppressive networks permits seizure spread.Brain : a journal of neurology · 2025Article
- Controversies in Cavernous Malformation Management: A Comprehensive Review of Current Literature.Journal of clinical medicine · 2025Review
- Association between enlarged perivascular space (ePVS) density and stereo-electroencephalography (SEEG) biomarkers of epileptogenicity.Epilepsia · 2025Article
- Epilepsy Surgery in Kazakhstan: Outcomes and the Role of Advanced Imaging.Journal of clinical medicine · 2025Article
- The Seizure Embedding Map: A Spatio-Temporal Transformer for Comparing Patients by Ictal Intracranial EEG Features at Scale.medRxiv : the preprint server for health sciences · 2025Article
- The molecular landscape of glioblastoma-associated epilepsy.Journal of molecular medicine (Berlin, Germany) · 2025Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Epilepsy is a debilitating neurological disorder affecting approximately 1 % of the world's population. Drug-resistant focal epilepsies are potentially surgically remediable. Although epilepsy surgery is dramatically underutilized among medically refractory patients, there is an expanding collection of evidence supporting its efficacy which may soon compel a paradigm shift. Of note is that a recent randomized controlled trial demonstrated that early resection leads to considerably better seizure outcomes than continued medical therapy in patients with pharmacoresistant temporal lobe epilepsy. In the present review, we provide a timely update of seizure freedom rates and predictors in resective epilepsy surgery, organized by the distinct pathological entities most commonly observed. Class I evidence, meta-analyses, and individual observational case series are considered, including the experiences of both our institution and others. Overall, resective epilepsy surgery leads to seizure freedom in approximately two thirds of patients with intractable temporal lobe epilepsy and about one half of individuals with focal neocortical epilepsy, although only the former observation is supported by class I evidence. Two common modifiable predictors of postoperative seizure freedom are early operative intervention and, in the case of a discrete lesion, gross total resection. Evidence-based practice guidelines recommend that epilepsy patients who continue to have seizures after trialing two or more medication regimens should be referred to a comprehensive epilepsy center for multidisciplinary evaluation, including surgical consideration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.