ArticleJournal of endocrinological investigation2014
Hypogonadism in aged hospitalized male patients: prevalence and clinical outcome.
Article in Journal of endocrinological investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Why does COVID-19 kill more elderly men than women? Is there a role for testosterone?Andrology · 2021Pooled it
- Testosterone supplementation and body composition: results from a meta-analysis of observational studies.Journal of endocrinological investigation · 2016Pooled it
- The Relationship Between Pituitary Axis Hormones and All-Cause Mortality in Hospitalized Patients with Chronic Diseases: A Prospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Novel Strategies to Promote Intensive Care Unit Recovery via Personalized Exercise, Nutrition, and Anabolic Interventions.Critical care clinics · 2025Review
- Hypogonadism is frequent in very old men with multimorbidity and is associated with anemia and sarcopenia.Zeitschrift fur Gerontologie und Geriatrie · 2024Article
- Low testosterone predicts hypoxemic respiratory insufficiency and mortality in patients with COVID-19 disease: another piece in the COVID puzzle.Journal of endocrinological investigation · 2022Article
- Examining Male Predominance of Severe COVID-19 Outcomes: A Systematic Review.Androgens: clinical research and therapeutics · 2022Review
- COVID-19 Pandemic and Male Fertility: Clinical Manifestations and Pathogenic Mechanisms.Biochemistry. Biokhimiia · 2021Review
- SARS-CoV-2 Pneumonia Affects Male Reproductive Hormone Levels: A Prospective, Cohort Study.The journal of sexual medicine · 2021Article
- Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients.Andrology · 2021Article
- Review
- Testosterone Deficiency Is a Risk Factor for Severe COVID-19.Frontiers in endocrinology · 2021Article
- Role of testosterone in COVID-19 patients - A double-edged sword?Medical hypotheses · 2020Article
- Role of anabolic testosterone agents and structured exercise to promote recovery in ICU survivors.Current opinion in critical care · 2020Review
- Screening for low testosterone is needed for early identification and treatment of men at high risk of mortality from Covid-19.Critical care (London, England) · 2020Article
- Associations Between Low Serum Testosterone and All-Cause Mortality and Infection-Related Hospitalization in Male Hemodialysis Patients: A Prospective Cohort Study.Kidney international reports · 2017Article
- The relationship of depression in asthma-chronic obstructive pulmonary disease overlap syndrome.PloS one · 2017Article
- How to define hypogonadism? Results from a population of men consulting for sexual dysfunction.Journal of endocrinological investigation · 2016Article
- Natural course of hypogonadism diagnosed during hospitalization in aged male patients.Endocrine · 2015Article
- Serum testosterone levels and mortality in men with CKD stages 3-4.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMale hypogonadism is common in the elderly and has been associated with increased risk of mortality. Our objective has been to assess the prevalence of primary and central hypogonadism in elderly male patients admitted to the hospital because of acute illness. We also evaluated the relationships between gonadal dysfunction and in-hospital mortality. PATIENTS AND
methods150 patients, aged ≥65 years, admitted during 2010 and 2011 in our geriatric unit, were studied. Serum concentrations total, bioavailable and free testosterone, as well as of follicle-stimulating hormone and luteinizing hormone were quantified in every patient. Hypogonadism was defined by the presence of serum testosterone levels lower than 200 ng/dl.
resultsHypogonadism was found in 80 patients (53.3 %). Serum gonadotropin concentrations were elevated in 43.7 % of these patients, whereas 41.3 % of hypogonadic patients showed normal and 15 % low gonadotropin concentrations. Respiratory tract infection and congestive heart failure were the main causes of hospitalization in hypogonadal men, whereas acute cerebrovascular disease was the main reason for admission in eugonadal patients. Of the 13 patients who died during hospitalization, 12 were hypogonadic. Patients who died showed significantly lower serum levels of total, free and bioavailable testosterone than those found in patients who survived.
conclusionOur results show that about half of patients admitted for acute illness have hypogonadism, mainly of non-hypergonadotropic type. Gonadal hypofunction is significantly related with in-hospital mortality. A low value of serum testosterone may be a predictor for mortality in elderly male patients.
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