ArticleThe Journal of general virology2014
Antigenic and genetic characterization of a divergent African virus, Ikoma lyssavirus.
Article in The Journal of general virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- A review of rabies in Southern African wildlife: Reservoir hosts, transmission dynamics, and control implications.Open veterinary journal · 2026Review
- Rabies Surveillance in Mainland Tanzania: A Scoping Review of Animal Rabies Occurrences (1993-2023).Pathogens (Basel, Switzerland) · 2025Article
- Evaluation of Taxonomic Characteristics of Matlo and Phala Bat Rabies-Related Lyssaviruses Identified in South Africa.Viruses · 2023Article
- Comparative Neutralization Activity of Commercial Rabies Immunoglobulin against Diverse Lyssaviruses.Vaccines · 2023Article
- Pseudotyped Viruses for Lyssavirus.Advances in experimental medicine and biology · 2023Article
- Applications of VirScan to broad serological profiling of bat reservoirs for emerging zoonoses.Frontiers in public health · 2023Article
- Article
- Assessing Rabies Vaccine Protection against a Novel Lyssavirus, Kotalahti Bat Lyssavirus.Viruses · 2021Article
- Genetic and Antigenetic Characterization of the Novel Kotalahti Bat Lyssavirus (KBLV).Viruses · 2021Article
- Lyssaviruses and the Fatal Encephalitic Disease Rabies.Frontiers in immunology · 2021Review
- Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups.Cell reports · 2020Article
- Article
- Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses.Current opinion in virology · 2019Review
- Bats and Viruses: Emergence of Novel Lyssaviruses and Association of Bats with Viral Zoonoses in the EU.Tropical medicine and infectious disease · 2019Review
- Antigenic variations of recent street rabies virus.Emerging microbes & infections · 2019Article
- Utilisation of Chimeric Lyssaviruses to Assess Vaccine Protection against Highly Divergent Lyssaviruses.Viruses · 2018Article
- Pathogenicity and Immunogenicity of Recombinant Rabies Viruses Expressing the Lagos Bat Virus Matrix and Glycoprotein: Perspectives for a Pan-Lyssavirus Vaccine.Tropical medicine and infectious disease · 2017Article
- Lagos Bat Virus Infection Dynamics in Free-Ranging Straw-Colored Fruit Bats (Eidolon helvum).Tropical medicine and infectious disease · 2017Article
- Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies.F1000Research · 2017Review
- The Global Phylogeography of Lyssaviruses - Challenging the 'Out of Africa' Hypothesis.PLoS neglected tropical diseases · 2016Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
In 2009, a novel lyssavirus (subsequently named Ikoma lyssavirus, IKOV) was detected in the brain of an African civet (Civettictis civetta) with clinical rabies in the Serengeti National Park of Tanzania. The degree of nucleotide divergence between the genome of IKOV and those of other lyssaviruses predicted antigenic distinction from, and lack of protection provided by, available rabies vaccines. In addition, the index case was considered likely to be an incidental spillover event, and therefore the true reservoir of IKOV remained to be identified. The advent of sensitive molecular techniques has led to a rapid increase in the discovery of novel viruses. Detecting viral sequence alone, however, only allows for prediction of phenotypic characteristics and not their measurement. In the present study we describe the in vitro and in vivo characterization of IKOV, demonstrating that it is (1) pathogenic by peripheral inoculation in an animal model, (2) antigenically distinct from current rabies vaccine strains and (3) poorly neutralized by sera from humans and animals immunized against rabies. In a laboratory mouse model, no protection was elicited by a licensed rabies vaccine. We also investigated the role of bats as reservoirs of IKOV. We found no evidence for infection among 483 individuals of at least 13 bat species sampled across sites in the Serengeti and Southern Kenya.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.