ArticleG3 (Bethesda, Md.)2014
Comparative genomic and transcriptomic analysis of wangiella dermatitidis, a major cause of phaeohyphomycosis and a model black yeast human pathogen.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 69 citations in OpenAlex.
- Genetic analysis of pigment production in the fungus Exophiala dermatitidis mutant strains obtained via nontargeted UV mutagenesis.G3 (Bethesda, Md.) · 2025Article
- Fungal Chitin Synthases: Structure, Function, and Regulation.Journal of fungi (Basel, Switzerland) · 2025Review
- Genetic, structural, and functional characterization of allomelanin from black yeast Exophiala viscosa, a chassis for fungal melanin production.Applied microbiology and biotechnology · 2025Article
- Polyextremotolerant, opportunistic, and melanin-driven resilient black yeast Exophiala dermatitidis in environmental and clinical contexts.Scientific reports · 2025Article
- Regulation of melanin production in fungi.Frontiers in fungal biology · 2025Review
- Deletion of the polyketide synthase-encoding gene pks1 prevents melanization in the extremophilic fungus Cryomyces antarcticus.IUBMB life · 2024Article
- 1,8-Dihydroxynaphthalene (DHN) melanin provides unequal protection to black fungi Knufia petricola and Cryomyces antarcticus from UV-B radiation.Environmental microbiology reports · 2024Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Black yeasts in hypersaline conditions.Applied microbiology and biotechnology · 2024Review
- Transcriptomic and genomic effects of gamma-radiation exposure on strains of the black yeastMicrobiology spectrum · 2023Article
- Characterization of a novel polyextremotolerant fungus, Exophiala viscosa, with insights into its melanin regulation and ecological niche.G3 (Bethesda, Md.) · 2023Article
- In host evolution of Exophiala dermatitidis in cystic fibrosis lung micro-environment.G3 (Bethesda, Md.) · 2023Article
- Genetic Engineering of the Rock InhabitantFrontiers in fungal biology · 2022Article
- Genomic characterization of polyextremotolerant black yeasts isolated from food and food production environments.Frontiers in fungal biology · 2022Article
- Phaeohyphomycosis in China.Frontiers in cellular and infection microbiology · 2022Review
- Phenotypic Characterization and Comparative Genomics of the Melanin-Producing YeastJournal of fungi (Basel, Switzerland) · 2021Article
- Chromoblastomycosis Caused byJournal of fungi (Basel, Switzerland) · 2021Article
- Transcriptomic and genomic changes associated with radioadaptation inComputational and structural biotechnology journal · 2021Article
- Shed Light in the DaRk LineagES of the Fungal Tree of Life-STRES.Life (Basel, Switzerland) · 2020Article
- An Overview of Genomics, Phylogenomics and Proteomics Approaches in Ascomycota.Life (Basel, Switzerland) · 2020Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Black or dark brown (phaeoid) fungi cause cutaneous, subcutaneous, and systemic infections in humans. Black fungi thrive in stressful conditions such as intense light, high radiation, and very low pH. Wangiella (Exophiala) dermatitidis is arguably the most studied phaeoid fungal pathogen of humans. Here, we report our comparative analysis of the genome of W. dermatitidis and the transcriptional response to low pH stress. This revealed that W. dermatitidis has lost the ability to synthesize alpha-glucan, a cell wall compound many pathogenic fungi use to evade the host immune system. In contrast, W. dermatitidis contains a similar profile of chitin synthase genes as related fungi and strongly induces genes involved in cell wall synthesis in response to pH stress. The large portfolio of transporters may provide W. dermatitidis with an enhanced ability to remove harmful products as well as to survive on diverse nutrient sources. The genome encodes three independent pathways for producing melanin, an ability linked to pathogenesis; these are active during pH stress, potentially to produce a barrier to accumulated oxidative damage that might occur under stress conditions. In addition, a full set of fungal light-sensing genes is present, including as part of a carotenoid biosynthesis gene cluster. Finally, we identify a two-gene cluster involved in nucleotide sugar metabolism conserved with a subset of fungi and characterize a horizontal transfer event of this cluster between fungi and algal viruses. This work reveals how W. dermatitidis has adapted to stress and survives in diverse environments, including during human infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.