ArticlePediatric nephrology (Berlin, Germany)2014
Prognostic relevance of early AKI according to pRIFLE criteria in children undergoing cardiac surgery.
Article in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Incidence of acute kidney injury-associated mortality in hospitalized children: a systematic review and meta-analysis.BMC nephrology · 2025Pooled it
- A meta-analysis of the incidence rate of postoperative acute kidney injury in patients with congenital heart disease.BMC nephrology · 2020Pooled it
- Persistent acute kidney injury and fluid accumulation with outcomes after the Norwood procedure: report from NEPHRON.Pediatric nephrology (Berlin, Germany) · 2024Article
- CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways.Molecular medicine (Cambridge, Mass.) · 2023Article
- Comparing the pRIFLE, AKIN, KDIGO, and modified KDIGO criteria in neonates after cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2022Article
- Blood pressure variability during pediatric cardiac surgery is associated with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2022Article
- Variation in clinical usefulness of biomarkers of acute kidney injury in young children undergoing cardiac surgery.Clinical and experimental pediatrics · 2020Article
- Risk Factors for Recurrent Acute Kidney Injury in Children Who Undergo Multiple Cardiac Surgeries: A Retrospective Analysis.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Article
- Recent Advances in Congenital Heart Surgery: Alternative Perfusion Strategies for Infant Aortic Arch Repair.Current cardiology reports · 2019Review
- Wider intraoperative glycemic fluctuation increases risk of acute kidney injury after pediatric cardiac surgery.Renal failure · 2018Observational
- Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery.JAMA pediatrics · 2018Article
- Risk Factors and Outcome of Acute Kidney Injury after Congenital Heart Surgery: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
- Acute kidney injury after pediatric liver transplantation: incidence, risk factors, and association with outcome.Journal of anesthesia · 2017Article
- Acute Kidney Injury After Pediatric Cardiac Surgery: A Secondary Analysis of the Safe Pediatric Euglycemia After Cardiac Surgery Trial.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Article
- AKI after pediatric cardiac surgery for congenital heart diseases-recent developments in diagnostic criteria and early diagnosis by biomarkers.Journal of intensive care · 2017Review
- Early detection of acute kidney injury after pediatric cardiac surgery.Progress in pediatric cardiology · 2016Article
- Acute Kidney Injury in Pediatric Heart Failure.Current cardiology reviews · 2016Review
- Cardiac biomarkers and acute kidney injury after cardiac surgery.Pediatrics · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute renal injury increases risk of death after cardiac surgery. The objective of the study was to evaluate the ability of the pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease (pRIFLE) criteria to characterize the development of postoperative renal damage in children after cardiopulmonary bypass (CPB) and to evaluate the relationship between the severity of kidney injury and mortality, pediatric intensive care unit (PICU) length of stay, and the duration of mechanical ventilation (MV).
methodsIn this retrospective study including children undergoing CPB surgery during a 3-year period in the PICU of a tertiary hospital, demographic, clinical, surgery-related, and postoperative clinical data were collected. Kidney damage was assessed with pRIFLE criteria.
resultsFour hundred and nine patients were included. Early acute kidney injury (AKI) was found in 82 patients (achieving categories Risk 44; Injury 16; Failure 22). Early AKI was associated with younger age (P = 0.010), longer CPB, deep hypothermic circulatory arrest (DHCA) use, ICU stay >12 days, MV >4 days, and death (P < 0.001). Controlling the effect of age, CPB, DHCA use, previous cardiac surgeries, and Risk Adjustment in Congenital Heart Surgery Surgical Severity Score (RACHS-1), early AKI development proved to predict ICU stay >12 days [odds ratio (OR) 3.5; 95% confidence interval (CI) 1.9-6.5, P < 0.001)] and need of MV >4 days (OR 5.1; 95% CI 2.6-10.2, P < 0.001).
conclusionsEarly AKI when evaluated with the pRIFLE criteria can predict prolonged ICU stay, need of prolonged MV, and mortality.
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