ArticleJournal of cell science2014
Sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesis.
Article in Journal of cell science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Article
- Quantitative proteomics reveals the dynamic proteome landscape of zebrafish embryos during the maternal-to-zygotic transition.iScience · 2024Article
- Nile Tilapia (International journal of molecular sciences · 2024Article
- PCP and Septins govern the polarized organization of the actin cytoskeleton during convergent extension.Current biology : CB · 2024Article
- Spatial regulation of microtubule-dependent transport by septin GTPases.Trends in cell biology · 2021Review
- A Ciliary View of the Immunological Synapse.Cells · 2019Review
- Inhibition ofJournal of cardiovascular development and disease · 2019Article
- Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Hereditary neuralgic amyotrophy in childhood caused by duplication within the SEPT9 gene: A family study.Cytoskeleton (Hoboken, N.J.) · 2019Article
- Septins in kidney: A territory little explored.Cytoskeleton (Hoboken, N.J.) · 2019Review
- Use of zebrafish to studyDisease models & mechanisms · 2018Review
- Septins restrict inflammation and protect zebrafish larvae from Shigella infection.PLoS pathogens · 2017Article
- The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.Scientific reports · 2017Article
- Uncovering the Roles of Septins in Cilia.Frontiers in cell and developmental biology · 2017Review
- Expression ofFrontiers in neuroanatomy · 2017Article
- sept7b is required for the differentiation of pancreatic endocrine progenitors.Scientific reports · 2016Article
- Visualization of in vivo septin ultrastructures by platinum replica electron microscopy.Methods in cell biology · 2016Article
- [Functional Characterization of Septin Complexes].Molekuliarnaia biologiiaReview
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The conserved septin family of filamentous small GTPases plays important roles in mitosis, cell migration and cell morphogenesis by forming scaffolds and diffusion barriers. Recent studies in cultured cells in vitro indicate that a septin complex of septin 2, 7 and 9 is required for ciliogenesis and cilia function, but septin function in ciliogenesis in vertebrate organs in vivo is not understood. We show that sept7b is expressed in ciliated cells in different tissues during early zebrafish development. Knockdown of sept7b by using morpholino antisense oligonucleotides caused misorientation of basal bodies and cilia, reduction of apical actin and the shortening of motile cilia in Kupffer's vesicle and pronephric tubules. This resulted in pericardial and yolk sac edema, body axis curvature and hydrocephaly. Notably, in sept7b morphants we detected strong left-right asymmetry defects in the heart and lateral plate mesoderm (situs inversus), reduced fluid flow in the kidney, the formation of kidney cysts and loss of glomerular filtration barrier function. Thus, sept7b is essential during zebrafish development for pronephric function and ciliogenesis, and loss of expression of sept7b results in defects that resemble human ciliopathies.
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Registered trials
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