ArticleJournal of the American Heart Association2014
Age-dependent sex effects on outcomes after pediatric cardiac surgery.
Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis on sex differences in mortality and neurodevelopment in congenital heart defects.Scientific reports · 2025Pooled it
- Gender and birth weight as risk factors for anastomotic stricture after esophageal atresia repair: a systematic review and meta-analysis.BMC pediatrics · 2020Pooled it
- Prognostic value of neutrophil-lymphocyte ratio, absolute lymphocyte count, and thrombocyte-lymphocyte ratio in predicting the outcomes of tetralogy of fallot primary repair.Frontiers in cardiovascular medicine · 2025Article
- Sex differences in metabolic adaptation in infants with cyanotic congenital heart disease.Pediatric research · 2024Article
- Promising results of a clinical feasibility study: CIRBP as a potential biomarker in pediatric cardiac surgery.Frontiers in cardiovascular medicine · 2024Article
- US Mortality Attributable to Congenital Heart Disease Across the Lifespan From 1999 Through 2017 Exposes Persistent Racial/Ethnic Disparities.Circulation · 2020Article
- Metabolic Response to Stress by the Immature Right Ventricle Exposed to Chronic Pressure Overload.Journal of the American Heart Association · 2019Article
- Mortality Following Pediatric Congenital Heart Surgery: An Analysis of the Causes of Death Derived From the National Death Index.Journal of the American Heart Association · 2018Article
- Current trends in racial, ethnic, and healthcare disparities associated with pediatric cardiac surgery outcomes.Congenital heart disease · 2017Article
- A population-based analysis of mortality in patients with Turner syndrome and hypoplastic left heart syndrome using the Texas Birth Defects Registry.Congenital heart disease · 2017Article
- Factors Affecting Length of Postoperative Hospitalization for Pediatric Cardiac Operations in a Large North American Registry (1982-2007).Pediatric cardiology · 2016Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundSex has been linked to differential outcomes for cardiovascular disease in adults. We examined potential sex differences in outcomes after pediatric cardiac surgery. METHODS AND
resultsWe retrospectively analyzed data from the Pediatric Cardiac Care Consortium (1982-2007) by using logistic regression to evaluate the effects of sex on 30-day within-hospital mortality after pediatric (<18 years old) cardiac operations and its interaction with age, risk category, z-score for weight, and surgical year for the whole cohort. Of 76 312 operations, 55% were in boys. Unadjusted mortality was similar for boys and girls (5.2% versus 5.0%, P=0.313), but boys were more likely to have cardiac surgery as a neonate and to have more complex operations. After adjustment, the overall test of any association between postsurgical mortality and sex was significant (P=0.002), but the overall test of any interaction was not (P=0.503). However, a potential age-dependent sex effect on postsurgical mortality was observed among infants subjected to high-risk operations, with girls doing worse during the first 6 months of life.
conclusionsPatient sex has a significant effect on mortality after pediatric cardiac operations, with an increased risk of death in early infancy for girls after high-risk cardiac operations. This age-dependent relationship supports a sex-related biological effect on postoperative cardiovascular stress.
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