Evidence map›Paper›PMID 24496073›Full record

ArticleJournal of Alzheimer's disease : JAD2014

Oxidative stress, testosterone, and cognition among Caucasian and Mexican-American men with and without Alzheimer's disease.

Rebecca L Cunningham, Meharvan Singh, Sid E O'Bryant, James R Hall, Robert C Barber

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rebecca L CunninghamDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Center FOR HER, University of North Texas Health Science Center, Fort Worth, TX, USA.
Meharvan SinghDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Center FOR HER, University of North Texas Health Science Center, Fort Worth, TX, USA.
Sid E O'BryantDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA.
James R HallDepartment of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA.
Robert C BarberDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA.
University of North Texas Health Science Center · USUniversity of North Texas · US

Funding

ROLE OF GLUTAMATE IN ALZHEIMER'S DISEASEP30AG012300 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI ROSENBERG, ROGER NEWMAN · 1994 to 2016
$26.6M
Protein Targets of Oxidative Brain AgingP01AG022550 · NIA · WEST VIRGINIA UNIVERSITY · PI SIMPKINS, JAMES W. · 2003 to 2013
$15.7M
ROLE OF MITHOCHONDRIAL ERB IN NEURONAL VULNDERABILITY TO NEUROTOXIC STRESSP01AG027956 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI SINGH, MEHARVAN · 2007 to 2017
$11.3M
A Blood-Based Screening Tool for Alzheimer's DiseaseR01AG039389 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E · 2012 to 2013
$608k
NIA NIH HHS AG022550NIA NIH HHS AG027956NIA NIH HHS P01 AG022550NIA NIH HHS P01 AG027956NIA NIH HHS P30 AG012300NIA NIH HHS P30AG12300NIA NIH HHS R01 AG039389NIA NIH HHS R01AG039389
6 · The paper itself

Abstract

backgroundThe use of testosterone among aging men has been increasing, but results from studies addressing the effectiveness of testosterone replacement therapy have been equivocal.

objectiveGiven our prior pre-clinical studies that reported a major influence of oxidative stress on testosterone's neuroprotective effects, we investigated whether the negative effects of testosterone on brain function were predicted by oxidative load.

methodsIn order to test our hypothesis, we determined whether circulating total testosterone and luteinizing hormone correlated with cognition in a subset of the Texas Alzheimer's Research & Care Consortium (TARCC) cohort, consisting of Caucasian (n = 116) and Mexican-American (n = 117) men. We also assessed whether oxidative stress (as indexed by homocysteine levels) modified this relationship between sex hormones and cognition, and whether the levels of two antioxidants, superoxide dismutase-1 and glutathione S-transferase (GST), varied as a function of circulating testosterone.

resultsIn a low oxidative stress environment, testosterone was positively associated with the level of the antioxidant, GST, while no deleterious effects on cognitive function were noted. In contrast, under conditions of high oxidative stress (homocysteine levels >12 μmol/L), testosterone and luteinizing hormone were associated with cognitive impairment, but only among Caucasians. The ethnic difference was attributed to significantly higher GST levels among Mexican-Americans.

conclusionWhile testosterone may be beneficial under conditions of low oxidative stress, testosterone appears to have negative consequences under conditions of elevated oxidative stress, but only in Caucasians. Mexican-Americans, however, were protected from any deleterious effects of testosterone, potentially due to higher levels of endogenous antioxidant defenses such as GST.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAnalysis of VarianceCognition DisordersCohort StudiesCross-Cultural ComparisonGlutathione TransferaseHumansIsoenzymesLuteinizing HormoneMaleMexican AmericansMiddle AgedNeuropsychological TestsOxidative Stressglutathione S-transferase alphaGlutathione TransferaseIsoenzymesLuteinizing HormoneTestosteroneAndrogensantioxidantshomocysteineluteinizing hormoneMexican American

Identifiers

PMID24496073
PMCPMC4219556
OpenAlexW2125868588

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.