Evidence map›Paper›PMID 24495993›Full record

ArticleEuropean journal of clinical nutrition2014

The role of dietary fat on the association between dietary amino acids and serum lipid profile in European adolescents participating in the HELENA Study.

S Bel-Serrat, T Mouratidou, I Huybrechts, M Cuenca-García, Y Manios, S Gómez-Martínez, D Molnár, A Kafatos, F Gottrand, K Widhalm and 7 more

Abstract read
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In one paragraph

Article in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 14 institutions in 9 countries.

S Bel-Serrat8217;Growth, Exercise, Nutrition and Development' (GENUD) Research Group, Department of Physiatry and Nursery, Faculty of Health Sciences, University of Zaragoza, Zaragoza, Spain.
T Mouratidou8217;Growth, Exercise, Nutrition and Development' (GENUD) Research Group, Department of Physiatry and Nursery, Faculty of Health Sciences, University of Zaragoza, Zaragoza, Spain.
I Huybrechts1] Department of Public Health, Faculty of Medicine and Health Sciences, University Hospital, Ghent University, Ghent, Belgium [2] International Agency for Research on Cancer (IARC), Dietary Exposure Assessment Group (DEX), Lyon, France.
M Cuenca-GarcíaDepartment of Physiology, Medicine School, Granada University, Granada, Spain.
Y ManiosDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
S Gómez-MartínezImmunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain.
D MolnárDepartment of Pediatrics, University of Pécs, Pécs-József, Hungary.
A KafatosDepartment of Social Medicine, Preventive Medicine and Nutrition Unit, University of Crete School of Medicine, Heraklion, Greece.
F GottrandInserm U995, Faculty of Medicine, University Lille 2, Lille, France.
K WidhalmDepartment of Pediatrics, Division of Clinical Nutrition and Prevention, Medical University of Vienna, Vienna, Austria.
M SjöströmDepartment of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
A WästlundDepartment of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
P StehleInstitut für Ernährungs- und Lebensmittelwissenschaften - Humanernährung, Rheinische Friedich-Wilhelms-Universität, Bonn, Germany.
E AzziniNational Research Institute for Food and Nutrition, INRAN, Rome, Italy.
K Vyncke1] Department of Public Health, Faculty of Medicine and Health Sciences, University Hospital, Ghent University, Ghent, Belgium [2] Research Foundation - Flanders (FWO), Brussels, Belgium.
M González-Gross1] ImFine Research Group, Departamento de Salud y Rendimiento Humano, Facultad de Ciencias de la Actividad Física y del Deporte-INEF, Universidad Politécnica de Madrid, Madrid, Spain [2] CIBER: CB12/03/30038 Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Instituto de Salud Carlos III (ISCIII), Spain.
L A Moreno8217;Growth, Exercise, Nutrition and Development' (GENUD) Research Group, Department of Physiatry and Nursery, Faculty of Health Sciences, University of Zaragoza, Zaragoza, Spain.
Universidad de Zaragoza · ESKarolinska Institutet · SEConsejo Superior de Investigaciones Científicas · ESDepartamento de Salud · ESGhent University Hospital · BEHarokopio University of Athens · GRInserm · FRIstituto Nazionale di Ricerca per gli Alimenti e la Nutrizione · ITMedical University of Vienna · ATResearch Foundation - Flanders · BEUniversidad de Granada · ESUniversity of Bonn · DEUniversity of Crete · GRUniversity of Pecs · HU

Funding

World Health Organization 001
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe objective of this study was to examine the relationship between amino acid (AA) intake and serum lipid profile in European adolescents from eight European cities participating in the cross-sectional (2006-2007) HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study, and to assess whether this association was independent of total fat intake. SUBJECTS/

methodsDiet, skinfold thickness, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), TC/HDL-c ratio, low-density lipoprotein cholesterol (LDL-c), apolipoprotein B (Apo B), apolipoprotein A1 (Apo A1) and Apo B/Apo A1 ratio were measured in 454 12.5- to 17.5-year-old adolescents (44% boys). Intake was assessed via two non-consecutive 24-h dietary recalls. Data on maternal education and sedentary behaviors were obtained via questionnaires. Physical activity was objectively measured by accelerometry.

resultsAlanine, arginine, asparaginic acid, glycine, histidine, lysine and serine intakes were inversely associated with serum TG concentrations in both boys and girls. Intake of other AA like alanine and/or arginine was also inversely associated with serum TC, LDL-c and Apo B/Apo A1 ratio only in girls. An inverse association was observed between intakes of alanine, isoleucine, leucine, methionine, serine, tryptophan, tyrosine and valine and TC/HDL-c ratio among female adolescents. Similar results were found in males for serine and tryptophan intakes. It is noteworthy, however, that associations were no longer significant in both genders when total fat intake was considered as a confounding factor.

conclusionsIn this sample of adolescents, the association between AA intakes and serum lipid profile did not persist when dietary fat was considered. Therefore, dietary interventions and health promotion activities should focus on fat intake to improve lipid profile and potentially prevent cardiovascular disease.

Indexed as

Feeding BehaviorAdolescentAmino AcidsBody Mass IndexBody WeightChildCholesterol, HDLCholesterol, LDLCross-Sectional StudiesDietDietary FatsDietary ProteinsEuropeFemaleHumansLinear ModelsAmino AcidsCholesterol, HDLCholesterol, LDLDietary FatsDietary ProteinsTriglycerides

Identifiers

PMID24495993
OpenAlexW2007970315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.