Evidence map›Paper›PMID 24495739›Full record

ArticleThe American journal of pathology2014

Morphine inhibits migration of tumor-infiltrating leukocytes and suppresses angiogenesis associated with tumor growth in mice.

Lisa Koodie, Hongyan Yuan, Jeffery A Pumper, Haidong Yu, Richard Charboneau, Sundaram Ramkrishnan, Sabita Roy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

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  9. Anesthesia and cancer recurrence: a narrative review.Anesthesia and pain medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lisa KoodieDepartment of Pharmacology, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; Department of Dentistry, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; Division of Basic Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
Hongyan YuanDivision of Basic Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
Jeffery A PumperDepartment of Dentistry, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
Haidong YuDivision of Basic Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
Richard CharboneauVeterans Affairs Medical Hospital, Minneapolis, Minnesota.
Sundaram RamkrishnanDepartment of Dentistry, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
Sabita RoyDepartment of Pharmacology, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; Department of Dentistry, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; Division of Basic Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota. Electronic address: royxx002@umn.edu.
University of Minnesota · USVeterans Health Administration · US

Funding

Subcellular Targeting/Packaging of Opioids/ReceptorsP50DA011806 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOH, HORACE · 1998 to 2012
$14.0M
MINNESOTA PAIN RESEARCH TRAINING PROGRAMT32DE007288 · NIDCR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HERZBERG, MARK C · 1996 to 2011
$8.8M
Opioid Abuse, opportunistic infection and NeuroAIDSR01DA012104 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROY, SABITA · 1999 to 2013
$3.7M
Gut microbiota disruption by Morphine and in the context of HIV infection contributes to sustained immune activationR01DA037843 · NIDA · UNIVERSITY OF MINNESOTA · PI JOHNSON, TIMOTHY J, ROY, SABITA · 2014 to 2018
$2.8M
Morphine, HIV proteins, wound healing and InfectionR01DA022935 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2007 to 2011
$1.7M
Role of microRNAs in opioid drug abuse induced persistent Inflammation and HIV diR01DA031202 · NIDA · UNIVERSITY OF MINNESOTA · PI RAMAKRISHNAN, SUNDARAM, ROY, SABITA · 2011 to 2015
$1.7M
Mechanism underlying Morphine modulation of gut barrier function in the Context oR01DA034582 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2013 to 2017
$1.6M
Antiangiogenic Gene Therapy of Ovarian and Breast CancersR01CA114340 · NCI · UNIVERSITY OF MINNESOTA · PI RAMAKRISHNAN, SUNDARAM · 2007 to 2011
$1.3M
Role of Mu Opioid Receptor in Immune FunctionK02DA015349 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROY, SABITA · 2002 to 2011
$977k
Opioid Drug abuse in the context of opportunistic infection increases susceptibilK05DA033881 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2012 to 2016
$661k
Morphine Induced Modulation of Tumor GrowthF31DA021005 · NIDA · UNIVERSITY OF MINNESOTA · PI KOODIE, LISA · 2006 to 2008
$92k
NCI NIH HHS CA114340NCI NIH HHS R01 CA114340NIDA NIH HHS F31 DA021005NIDA NIH HHS F31-DA021005-01NIDA NIH HHS K02 DA 015349NIDA NIH HHS K02 DA015349NIDA NIH HHS K05 DA033881NIDA NIH HHS P50 DA 011806NIDA NIH HHS P50 DA011806NIDA NIH HHS R01 DA012104NIDA NIH HHS R01 DA 022935NIDA NIH HHS R01 DA022935NIDA NIH HHS R01 DA031202NIDA NIH HHS R01 DA034582NIDA NIH HHS R01 DA037843NIDA NIH HHS R01 DA 12104NIDCR NIH HHS T32 DE007288NIDCR NIH HHS T32DE007288
6 · The paper itself

Abstract

Tumor cells secrete factors that stimulate the migration of peripheral blood leukocytes and enhance tumor progression by affecting angiogenesis. In these studies, we investigated the effect of morphine, a known immunosuppressant, on leukocyte migration and recruitment to conditioned media derived from long-term cultures of mouse Lewis lung carcinoma cells. Our results indicate that morphine treatment reduced the migration and recruitment of tumor-infiltrating leukocytes into Matrigel plugs and polyvinyl alcohol sponges containing conditioned media derived from long-term cultures of mouse Lewis lung carcinoma cells when compared with placebo. A reciprocal increase in peripheral blood leukocytes was observed at the time of plug or sponge removal in morphine-treated mice. Decreased angiogenesis was observed in conditioned media derived from long-term cultures of mouse Lewis lung carcinoma cells Matrigel plugs taken from morphine-treated wild-type mice when compared with placebo but was abolished in morphine-treated μ-opioid receptor knockout mice. In addition, in vitro studies using trans-well and electric cell substrate impedance sensing system studies reveal for the first time morphine's inhibitory effects on leukocyte migration and their ability to transmigrate across an activated endothelial monolayer. Taken together, these studies indicate that morphine treatment can potentially decrease leukocyte transendothelial migration and reduce angiogenesis associated with tumor growth. The use of morphine for cancer pain management may be beneficial through its effects on angiogenesis.

Indexed as

AnimalsCarcinoma, Lewis LungCell Line, TumorCulture Media, ConditionedFemaleHumansImmunosuppressive AgentsLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred C57BLMice, KnockoutMorphineNeovascularization, PathologicReceptors, Opioid, muTransendothelial and Transepithelial MigrationCulture Media, ConditionedImmunosuppressive AgentsMorphineReceptors, Opioid, mu

Identifiers

PMID24495739
PMCPMC3969995
OpenAlexW2077779607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.