ArticleDiagnostic pathology2014
Differences in breast carcinoma immunohistochemical subtypes between immigrant Arab and European women.
Article in Diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Identifying hormone receptor-positive breast cancer subtypes with recurrence scores derived from pathological data without Ki-67 indices: a clinicopathological study of breast cancer survival in West Asia.Virchows Archiv : an international journal of pathology · 2026Article
- Breast cancer-specific survival among immigrants and non-immigrants invited to BreastScreen Norway.Journal of migration and health · 2024Article
- Early screening outcomes among non-immigrants and immigrants targeted by BreastScreen Norway, 2010-2019.Scandinavian journal of public health · 2023Article
- Incidence of breast cancer subtypes in immigrant and non-immigrant women in Norway.Breast cancer research : BCR · 2022Article
- Molecular Spectra and Frequency Patterns of Somatic Mutations in Arab Women with Breast Cancer.The oncologist · 2021Article
- Performance measures among non-immigrants and immigrants attending BreastScreen Norway: a population-based screening programme.European radiology · 2019Article
- The Advent of Salivary Breast Cancer Biomarker Detection Using Affinity Sensors.Sensors (Basel, Switzerland) · 2019Review
- Analysis of Racial/Ethnic Representation in Select Basic and Applied Cancer Research Studies.Scientific reports · 2018Article
- Breast cancer in Iraq is associated with a unimodally distributed predominance of luminal type B over luminal type A surrogates from young to old age.BMC women's health · 2017Article
- Expression of the glucocorticoid receptor in breast cancer-associated fibroblasts.Molecular and clinical oncology · 2016Article
- Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma.Molecular and clinical oncology · 2016Article
- Gene-expression signature functional annotation of breast cancer tumours in function of age.BMC medical genomics · 2015Article
- Molecular breast cancer subtypes and therapies in a public hospital of northeastern Brazil.BMC women's health · 2014Article
- Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer.Oncology reports · 2014Article
- Association of TRPS1 gene with different EMT markers in ERα-positive and ERα-negative breast cancer.Diagnostic pathology · 2014Article
- Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations.Diagnostic pathology · 2014Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a dearth of information on the clinicopathological differences, including the molecular subtypes, of breast carcinomas from immigrant Arab women in Europe. Therefore, the aim of our study was to examine and compare these features in immigrant Arab/Moroccan patients with those of European women.
methodsIncluded in this study were 441 cases of breast cancer: 91 Arab/Moroccan women and 350 European women. Age, size, grade, node involvement, and immunohistochemical profile (classification into the following subtypes: luminal A, luminal B, HER2 +/ER -, and triple negative) were analyzed.
resultsThe average age of breast cancer presentation in Arab women is almost a decade earlier than in European women (49 versus 60 years old; p = 0.00001). Arab patients also had a higher average tumor size (25 mm versus 19 mm; p =0,008) and more grade 3 and less grade 1 tumors (p = 0.02). It should be noted, however, that this variability in the size and grade do not appear statistically significant when compared in Arab and European patients under 50 years old. In contrast, independent of age, the immunohistochemical subtypes were different between the two populations, with a greater number of luminal B subtype and fewer luminal A subtype (p <0.02) in Arab patients.
conclusionsArab patients with breast carcinoma have different clinicopathological features from European patients, mainly the age of cancer presentation. Their immunohistochemical profile is also different, with more luminal B and less luminal A subtypes, suggesting that there are not only clinicopathological differences but also disparities in the expression profiling in these women. VIRTUAL SLIDE: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2104813621113288.
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