ArticleJournal of the Formosan Medical Association = Taiwan yi zhi2014
Viral infections associated with Kawasaki disease.
Article in Journal of the Formosan Medical Association = Taiwan yi zhi, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00154596 (Etiology Study of Kawasaki Disease--A Prospective Household and Case Control Study), which is not on this map. Cited by 136 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Etiology Study of Kawasaki Disease--A Prospective Household and Case Control Study
Who cites it
136 citing papers in PubMed, 6 syntheses or guidelines pooled it, 238 citations in OpenAlex.
- Roles of Oxidative Injury and Nitric Oxide System Derangements in Kawasaki Disease Pathogenesis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Systemic inflammatory syndrome in COVID-19-SISCoV study: systematic review and meta-analysis.Pediatric research · 2022Pooled it
- Kawasaki Disease Shock Syndrome vs Classical Kawasaki Disease: A Meta-analysis and Comparison With SARS-CoV-2 Multisystem Inflammatory Syndrome.The Canadian journal of cardiology · 2021Pooled it
- Coronavirus disease 2019 (COVID-19): A systematic review of 133 Children that presented with Kawasaki-like multisystem inflammatory syndrome.Journal of medical virology · 2021Pooled it
- Phenotype, Susceptibility, Autoimmunity, and Immunotherapy Between Kawasaki Disease and Coronavirus Disease-19 Associated Multisystem Inflammatory Syndrome in Children.Frontiers in immunology · 2021Pooled it
- Kawasaki-like disease in children with COVID-19.Rheumatology international · 2020Pooled it
- Etiology Model of Kawasaki Disease and Multisystem Inflammatory Syndromes: Mast Cell Activation.Current issues in molecular biology · 2026Article
- Patterned Clues in an Infant With Annular Rash and Seizures Revealing Kawasaki Disease.Case reports in pediatrics · 2026Article
- Cholestasis as a complication in Kawasaki disease: an atypical clinical presentation.European journal of medical research · 2025Article
- A study on the transcriptional characteristics of novel HERV gene in the blood of children with Kawasaki disease and its correlation with the disease.Microbiology spectrum · 2025Article
- Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases.Disease models & mechanisms · 2025Article
- Differentiating Kawasaki Disease and Multisystem Inflammatory Syndrome in Children Using Blood Composite Scores: Insights into Clinical Outcomes and Predictive Indices.Pediatric cardiology · 2025Article
- Clinical characteristics of cervical lymphadenopathy in Kawasaki disease and the generation of related cervical complications: a retrospective cohort study.European journal of medical research · 2025Article
- Concurrent infections in children with Kawasaki disease: lessons learned over 26 years.Immunologic research · 2025Article
- Associations of infection burden with Kawasaki disease in a population-based setting during 30 years.RMD open · 2025Article
- Multisystem inflammatory syndrome in children and Kawasaki disease.Frontiers in immunology · 2025Review
- Clinical characteristics of Kawasaki disease with pulmonary radiographic abnormalities and its impact on the incidence of coronary artery lesions: a randomized retrospective cohort study.Frontiers in pediatrics · 2025Article
- Concurrent Coxsackievirus A6 Infection and Kawasaki Disease: A Case Report.Reports (MDPI) · 2024Article
- Kawasaki disease before and during the COVID-19 pandemic: a single-center comparative study in Switzerland.BMC pediatrics · 2024Article
- Kawasaki Disease and Respiratory Viruses: Ecological Spatiotemporal Analysis.JMIR public health and surveillance · 2024Article
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeKawasaki disease (KD) is a disease of unknown cause. To investigate the infectious etiology of Kawasaki disease, we initiated a prospective case-control study to investigate possible links between common viral infections and Kawasaki disease.
methodsWe enrolled 226 children with KD and 226 age- and sex-matched healthy children from February 2004 to March 2010. Throat and nasopharyngeal swabs were taken for both viral isolation and polymerase chain reaction (PCR) for various viruses.
resultsThe mean age of the 226 KD cases was 2.07 years, and the male to female ratio was 1.43 (133 boys to 93 girls). Their mean fever duration was 7.5 days with a mean peak temperature of 39.7°C. In addition to the typical symptoms of fever, neck lymphadenopathy, lip fissure and/or strawberry tongue, skin rash, nonpurulent bulbar conjunctivitis, palm/sole erythema, and induration followed by periungual desquamation, these KD cases also exhibited cough (69%), rhinorrhea (58%), and diarrhea (45%). Cases of KD had a significantly higher positive rate of viral isolation in comparison with the control group (7.5% vs. 2.2%, p = 0.02). Compared with the control group, cases of KD were more likely to have overall positive rates of viral PCR (50.4% vs. 16.4%, p < 0.001) and for various viruses including enterovirus (16.8% vs. 4.4%, p < 0.001), adenovirus (8.0% vs. 1.8%, p = 0.007), human rhinovirus (26.5% vs. 9.7%, p < 0.001), and coronavirus (7.1% vs. 0.9%, p = 0.003).
conclusionWe found that some common respiratory viruses, such as adenoviruses, enteroviruses, rhinoviruses, and coronaviruses, were associated with KD cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.