ArticlePsychiatry research2014
Pharmaco-MEG evidence for attention related hyper-connectivity between auditory and prefrontal cortices in ADHD.
Article in Psychiatry research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
- Altered auditory attention and functional connectivity in the auditory cortex of children with Attention-Deficit/Hyperactivity Disorder.BMC psychiatry · 2025Article
- Top-down auditory attention modulates neural responses more strongly in neurotypical than ADHD young adults.Brain research · 2023Article
- Sound localization and auditory selective attention in school-aged children with ADHD.Frontiers in neuroscience · 2022Article
- The human motor cortex microcircuit: insights for neurodegenerative disease.Nature reviews. Neuroscience · 2020Review
- Electrophysiological Brain Connectivity: Theory and Implementation.IEEE transactions on bio-medical engineering · 2019Article
- Functional network integration and attention skills in young children.Developmental cognitive neuroscience · 2018Article
- By our bootstraps: Comparing methods for measuring auditory 40 Hz steady-state neural activity.Psychophysiology · 2017Article
- Neuroimaging with magnetoencephalography: A dynamic view of brain pathophysiology.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Translating Adult Electrophysiology Findings to Younger Patient Populations: Difficulty Measuring 40-Hz Auditory Steady-State Responses in Typically Developing Children and Children with Autism Spectrum Disorder.Developmental neuroscience · 2016Article
- MEG Analysis of Neural Interactions in Attention-Deficit/Hyperactivity Disorder.Computational intelligence and neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The ability to attend to particular stimuli while ignoring others is crucial in goal-directed activities and has been linked with prefrontal cortical regions, including the dorsolateral prefrontal cortex (DLPFC). Both hyper- and hypo-activation in the DLPFC has been reported in patients with attention-deficit/hyperactivity disorder (ADHD) during many different cognitive tasks, but the network-level effects of such aberrant activity remain largely unknown. Using magnetoencephalography (MEG), we examined functional connectivity between regions of the DLPFC and the modality-specific auditory cortices during an auditory attention task in medicated and un-medicated adults with ADHD, and those without ADHD. Participants completed an attention task in two separate sessions (medicated/un-medicated), and each session consisted of two blocks (attend and no-attend). All MEG data were coregistered to structural MRI, corrected for head motion, and projected into source space. Subsequently, we computed the phase coherence (i.e., functional connectivity) between DLPFC regions and the auditory cortices. We found that un-medicated adults with ADHD exhibited greater phase coherence in the beta (14-30Hz) and gamma frequency (30-56Hz) range in attend and no-attend conditions compared to controls. Stimulant medication attenuated these differences, but did not fully eliminate them. These results suggest that aberrant bottom-up processing may engulf executive resources in ADHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.