ArticleBMC cancer2014
Peritumoral ductular reaction: a poor postoperative prognostic factor for hepatocellular carcinoma.
Article in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Ductular reaction in non-alcoholic fatty liver disease: When Macbeth is perverted.World journal of hepatology · 2023Review
- Pathophysiological Roles of Ductular Reaction in Liver Inflammation and Hepatic Fibrogenesis.Cellular and molecular gastroenterology and hepatology · 2023Article
- Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver.Science advances · 2021Article
- Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocarcinoma.BMC gastroenterology · 2020Article
- Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns.Annual review of pathology · 2020Review
- SESN2 correlates with advantageous prognosis in hepatocellular carcinoma.Diagnostic pathology · 2017Article
- Peritumoral EpCAM Is an Independent Prognostic Marker after Curative Resection of HBV-Related Hepatocellular Carcinoma.Disease markers · 2017Article
- Clinicopathological significance of STAT4 in hepatocellular carcinoma and its effect on cell growth and apoptosis.OncoTargets and therapy · 2016Article
- Management of hepatocellular carcinoma: Predictive value of immunohistochemical markers for postoperative survival.World journal of hepatology · 2015Review
- Aging impairs induction of redox factor-1 after heat stress: a potential mechanism for heat-induced liver injury.International journal of physiology, pathophysiology and pharmacology · 2015Article
- Proliferative ductular reactions correlate with hepatic progenitor cell and predict recurrence in HCC patients after curative resection.Cell & bioscience · 2014Article
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10 authors.
Funding
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Abstract
backgroundThe role of ductular reaction (DR) in hepatocellular carcinoma (HCC) remains to be elucidated.
methodsIn this study, we tried to uncover possible effect by correlating peritumoral DR in a necroinflammatory microenvironment with postoperative prognosis in HCC. The expression of peritumoral DR/CK19 by immunohistochemistry, necroinflammation and fibrosis were assessed from 106 patients receiving curative resection for HCC. Prognostic values for these and other clinicopathologic factors were evaluated.
resultsPeritumoral DR significantly correlated with necroinflammation (r = 0.563, p = 3.4E-10), fibrosis (r = 0.435, p = 3.1E-06), AFP level (p = 0.010), HBsAg (p = 4.9E-4), BCLC stage (p = 0.003), TNM stage (p = 0.002), multiple nodules (p = 0.004), absence of tumor capsule (p = 0.027), severe microscopic vascular invasion (p = 0.031) and early recurrence (p = 0.010). Increased DR was significantly associated with decreased RFS/OS (p = 4.8E-04 and p = 2.6E-05, respectively) in univariate analysis and were identified as an independent prognostic factor (HR = 2.380, 95% CI = 1.250-4.534, p = 0.008 for RFS; HR = 4.294, 95% CI = 2.255-8.177, p = 9.3E-6 for OS) in multivariate analysis.
conclusionsThese results suggested that peritumoral DR in a necroinflammatory microenvironment was a poor prognostic factor for HCC after resection.
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