ArticleJournal of proteome research2014
Deep proteome mapping of mouse kidney based on OFFGel prefractionation reveals remarkable protein post- translational modifications.
Article in Journal of proteome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Integrative multi-omics analysis of autism spectrum disorder reveals unique microbial macromolecules interactions.Journal of advanced research · 2025Article
- Enrichment of Intact Glycopeptides Using Strong Anion Exchange and Electrostatic Repulsion Hydrophilic Interaction Chromatography.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Thermotolerance and plasticity of camel somatic cells exposed to acute and chronic heat stress.Journal of advanced research · 2020Article
- Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis.Journal of proteome research · 2017Article
- Proteoform-Specific Insights into Cellular Proteome Regulation.Molecular & cellular proteomics : MCP · 2016Article
- Comprehensive data analysis of human ureter proteome.Data in brief · 2016Article
- Phosphoproteomics in the Age of Rapid and Deep Proteome Profiling.Analytical chemistry · 2016Review
- A proteomic glimpse into human ureter proteome.Proteomics · 2016Article
- Behavioral and proteomic analysis of stress response in zebrafish (Danio rerio).Journal of proteome research · 2015Article
- New proteomic insights on the role of NPR-A in regulating self-renewal of embryonic stem cells.Stem cell reviews and reports · 2014Article
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Authors and funding
9 authors.
Funding
Abstract
Performing a comprehensive nonbiased proteome analysis is an extraordinary challenge due to sample complexity and wide dynamic range, especially in eukaryotic tissues. Thus, prefractionation steps conducted prior to mass spectrometric analysis are critically important to reduce complex biological matrices and allow in-depth analysis. Here we demonstrated the use of OFFGel prefractionation to identify more low abundant and hydrophobic proteins than in a nonfractionated sample. Moreover, OFFGel prefractionation of a kidney protein sample was able to unveil protein functional relevance by detecting PTMs, especially when prefractionation was augmented with a targeted enrichment strategy such as TiO₂ phospho-enrichment. The OFFGel-TiO₂ combination used in this study was comparable to other global phosphoproteomics approaches (SCX-TiO₂, ERLIC-TiO₂, or HILIC-TiO₂). The detailed mouse kidney proteome with the phosphopeptide enrichment presented here serves as a useful platform for a better understanding of how the renal protein modification machinery works and, ultimately, will contribute to our understanding of pathological processes as well as normal physiological renal functions.
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