ReviewIranian journal of basic medical sciences2013
Pathogenesis of epilepsy: challenges in animal models.
Review in Iranian journal of basic medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Short-Term Renal Effects of Add-On Levetiracetam in Client-Owned Dogs with Idiopathic Epilepsy Receiving Phenobarbital: A Four-Week Prospective Study.Veterinary sciences · 2026Article
- Ethnopharmacological relevance of Chinese medicinal materials and natural products in epilepsy: a critical multi-target review integrating neurons, glia and inflammatory signaling.Frontiers in pharmacology · 2026Review
- Differential roles of NaeLife · 2025Article
- An efficient neural network of cooperating serotonergic and noradrenergic neurons in modulating sudden unexpected death in epilepsy.International journal of biological sciences · 2025Article
- Silencing epileptic storms: targeting miRNA-lncRNA crosstalk in astrocytes and microglia to disarm neuroinflammatory triggers.Frontiers in molecular neuroscience · 2025Review
- Classification of Current Experimental Models of Epilepsy.Brain sciences · 2024Review
- Chemoarchitectural signatures of subcortical shape alterations in generalized epilepsy.Communications biology · 2024Article
- Synthesis and Psychotropic Properties of Novel Condensed Triazines for Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Biomolecular mechanisms of epileptic seizures and epilepsy: a review.Acta epileptologica · 2023Review
- Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences.International journal of molecular sciences · 2022Article
- Neuroprotective Effect ofFrontiers in neuroscience · 2022Article
- Effects of rosmarinic acid on nervous system disorders: an updated review.Naunyn-Schmiedeberg's archives of pharmacology · 2020Review
- Comparison of three administration modes for establishing a zebrafish seizure model induced by N-Methyl-D-aspartic acid.World journal of psychiatry · 2020Article
- Epileptic seizures.Discoveries (Craiova, Romania) · 2020Review
- LncRNA UCA1 Suppresses the Inflammation Via Modulating miR-203-Mediated Regulation of MEF2C/NF-κB Signaling Pathway in Epilepsy.Neurochemical research · 2020Article
- Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.BioMed research international · 2020Observational
- Whether the Presence of Depressions Increases Stigmatization of People with Epilepsy?Materia socio-medica · 2018Article
- The Progress of Epilepsy after Stroke.Current neuropharmacology · 2018Review
- Article
- Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model - Phenytoin and Valproate, Lamotrigine and Valproate.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, several investigations have embarked on advancing knowledge of the mechanism underlying epileptogenesis, understanding in mechanism of pharmacoresistance and discovering antiepileptogenic or disease-modifying therapy. Animal models play a crucial and significant role in providing additional insight into mechanism of epileptogenesis. With the help of these models, epileptogenesis process has been demonstrated to be involved in various molecular and biological pathways or processes. Hence, this article will discuss the known and postulated mechanisms of epileptogenesis and challenges in using the animal models.
Indexed as
Identifiers
24494063PMC3909622W1943960223What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.