Evidence map›Paper›PMID 24493794›Full record

SynthesisHuman molecular genetics2014

Meta-analysis of loci associated with age at natural menopause in African-American women.

Christina T L Chen, Ching-Ti Liu, Gary K Chen, Jeanette S Andrews, Alice M Arnold, Jill Dreyfus, Nora Franceschini, Melissa E Garcia, Kathleen F Kerr, Guo Li and 46 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Selected Genetic Factors Associated with Primary Ovarian Insufficiency.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Genetic Determinants of Premature Menopause in A Mashhad Population Cohort.International journal of fertility & sterility · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Genetics of human female infertility†.Biology of reproduction · 2019
    Review
  19. Estrogen activates Alzheimer's disease genes.Alzheimer's & dementia (New York, N. Y.) · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors at 20 institutions in 1 country.

Christina T L ChenDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA ctchen@fhcrc.org rajkovic@upmc.edu murabito@bu.edu christopher.haiman@med.usc.edu.
Ching-Ti LiuDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Gary K ChenDepartment of Preventive Medicine.
Jeanette S AndrewsDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Alice M ArnoldDepartment of Biostatistics.
Jill DreyfusDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health.
Melissa E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD 20814, USA.
Kathleen F KerrDepartment of Biostatistics.
Guo LiDepartment of Medicine, University of Washington, Seattle, WA 98195, USA.
Kurt K LohmanDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Solomon K MusaniUniversity of Mississippi Medical Center, Jackson, MS 39216, USA.
Michael A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Leslie J RaffelDepartment of Pediatrics and Biomedical Sciences.
Jennifer SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Christine B AmbrosoneDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Elisa V BanderaThe Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Leslie BernsteinDivision of Cancer Etiology, Department of Population Science, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
Angela BrittonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Robert G BrzyskiDepartment of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Anne CappolaDivision of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christopher S CarlsonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
David CouperDepartment of Biostatistics, Gillings School of Global Public Health.
Sandra L DemingDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Mark O GoodarziDivision of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Gerardo HeissDepartment of Epidemiology, Gillings School of Global Public Health.
Esther M JohnDivision of Epidemiology, Department of Health Research & Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.
Xiaoning LuDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA Division of Clinical Informatics, Beth Israel Deaconess Medical Center, Boston, MA 02118, USA.
Loic Le MarchandEpidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA.
Kristin MarcianteDepartment of Medicine, University of Washington, Seattle, WA 98195, USA.
Barbara McknightDepartment of Biostatistics.
Robert MillikanDepartment of Epidemiology, Gillings School of Global Public Health Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.
Nora L NockDepartment of Epidemiology and Biostatistics, Case Western University, Cleveland, OH 44106, USA.
Andrew F OlshanDepartment of Epidemiology, Gillings School of Global Public Health Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.
Michael F PressDepartment of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.
Dhananjay VaiydaDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Nancy F WoodsBiobehavioral Nursing and Health Systems, University of Washington, Seattle, WA 98109, USA.
Herman A TaylorUniversity of Mississippi Medical Center, Jackson, MS 39216, USA.
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Michele K EvansHealth Disparities Research Section, Clinical Research Branch.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD 20814, USA.
Brian E HendersonDepartment of Preventive Medicine.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Thomas H MosleyDivision of Geriatric Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Bruce PsatyDepartments of Medicine, Epidemiology and Health Services, University of Washington and Group Health Research Institute, Seattle, WA, USA.
Melissa WellonsSchool of Medicine, Vanderbilt University, Nashville, TN 37240, USA.
Beverly G WindhamDivision of Geriatric Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Alan B ZondermanLaboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
L Adrienne CupplesDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Ellen W DemerathDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Christopher HaimanDepartment of Preventive Medicine ctchen@fhcrc.org rajkovic@upmc.edu murabito@bu.edu christopher.haiman@med.usc.edu.
Joanne M MurabitoNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA ctchen@fhcrc.org rajkovic@upmc.edu murabito@bu.edu christopher.haiman@med.usc.edu.
Aleksandar RajkovicDepartment of Obstetrics, Gynecology and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 15213, USA ctchen@fhcrc.org rajkovic@upmc.edu murabito@bu.edu christopher.haiman@med.usc.edu.
Fred Hutch Cancer Center · USNational Institute on Aging · USUniversity of Michigan–Ann Arbor · USUniversity of Mississippi Medical Center · USUniversity of Washington · USVanderbilt University · USWake Forest University · USBoston University · USFramingham Heart Study · USNational Institutes of Health · USUniversity of Minnesota · USBeckman Research InstituteCancer Research Center · USCedars-Sinai Medical Center · USJackson Memorial Hospital · USJohns Hopkins Medicine · USNeurobehavioral Systems · USRoswell Park Comprehensive Cancer Center · USRutgers Cancer Institute of New JerseyStanford University · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KATHERINE A. HOADLEY · 1992 to 2026
$59.3M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Women's Health Initiative Clinical Coordinating CenterN01WH22110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRENTICE, ROSS L · 2007 to 2010
$22.5M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
Intramural NIH HHSNCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR001120NCI NIH HHS P50 CA058223NCI NIH HHS P50-CA58223NCI NIH HHS R01 CA063464NCI NIH HHS R01-CA63464NCI NIH HHS R37 CA054281NCI NIH HHS R37-CA54281NCRR NIH HHS UL1-RR-024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1-RR-025005NCRR NIH HHS UL1RR025005NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL1RR033176NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHLBI NIH HHS HHSN268200900055CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL080295NHLBI NIH HHS HL087660NHLBI NIH HHS HL54457NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095170NHLBI NIH HHS N01 HC095171NHLBI NIH HHS N01 HC095172NHLBI NIH HHS N01 HC-55222NHLBI NIH HHS N01-HC-65226NHLBI NIH HHS N01-HC-85079NHLBI NIH HHS N01-HC-85080NHLBI NIH HHS N01-HC-85081NHLBI NIH HHS N01-HC-85082NHLBI NIH HHS N01-HC-85083NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS N01-HC-85239NHLBI NIH HHS N01HC95159-69NHLBI NIH HHS N01-HC-95170NHLBI NIH HHS N01-HC-95171NHLBI NIH HHS N01-HC-95172NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01-HL-071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01-HL-071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01-HL-071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01-HL-071251NHLBI NIH HHS R01 HL071252NHLBI NIH HHS R01-HL-071252NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01-HL-071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01-HL-071259NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01HL59367NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U10 HL054457NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS AG-023629NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01AG62101NIA NIH HHS N01AG62103NIA NIH HHS N01AG62106NIA NIH HHS R21 AG032598NIA NIH HHS R21AG032598NIA NIH HHS Z01-AG000513NICHD NIH HHS R01 HD044858NICHD NIH HHS R01 HD070647NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK079637NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30-ES10126PHS HHS HHSN268200625226CPHS HHS HHSN5215810550000234WHI NIH HHS N01 WH022110WHI NIH HHS N01WH22110WHI NIH HHS N01WH24152WHI NIH HHS N01WH32100-2WHI NIH HHS N01WH32105-6WHI NIH HHS N01WH32108-9WHI NIH HHS N01WH32111-13WHI NIH HHS N01WH32115WHI NIH HHS N01WH32118-32119WHI NIH HHS N01WH32122WHI NIH HHS N01WH42107-26WHI NIH HHS N01WH42129-32WHI NIH HHS N01WH44221
6 · The paper itself

Abstract

Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

Indexed as

Age FactorsBlack or African AmericanChromosomes, HumanFemaleGenetic LociGenetic VariationGenome-Wide Association StudyHumansMenopauseUnited StatesWhite People

Identifiers

PMID24493794
PMCPMC4030781
OpenAlexW2162230245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.